Toxicological interaction of multi-component mixtures to Vibrio qinghaiensis sp.-Q67 induced by at least three components.
Toxicological interaction of multi-component mixtures to Vibrio qinghaiensis sp.-Q67 induced by at least three components.
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DOI：
10.1016/j.scitotenv.2018.04.023
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发表时间：
2018-09
期刊：
影响因子：
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通讯作者：
Ya-Qian Xu;Shu-Shen Liu;Ye Fan;Kai Li
中科院分区：
文献类型：
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作者：
Ya-Qian Xu;Shu-Shen Liu;Ye Fan;Kai Li
研究人员已经指出，抗生素多粘菌素B硫酸盐（POL）是淡水发光细菌（Vibrio qinghaiensissp.-）中诱导时间依赖性拮抗作用的关键组分。Q67，暴露在离子液体、农药和抗生素的三元混合体系中。然而，前面的陈述仅限于三元和四元混合物，而没有考虑二元体系等情况。为了更全面、系统地证明POL对拮抗作用的直接诱导作用，本文进行了两大类实验（在非拮抗三元体系中加入POL和将具有拮抗作用的POL三元体系分解为二元体系）。结果表明，四元混合物体系（在非拮抗性三元混合物中加入POL，向上验证）在实验的某个时间点对大多数射线表现出拮抗作用。然而，通过将具有POL的拮抗性三元混合物分解为二元混合物（向下验证），实验中所有时间点的二元混合物的联合毒性是相加的。显然，POL仅在三元和四元混合物中对拮抗作用有显著贡献，而在二元混合物中没有。我们可以得出一个新的结论，即多组分混合物的拮抗作用是由至少三种组分（包括POL）诱导的，具有复杂的化学相互作用。因此，以POL的对抗性影响为例，未来的环境保护实践者和学术研究者在评估某些化学品造成污染的影响和反应时，应该构建更多的混合物情景。
It has been stated by researchers that the antibiotic polymyxin B sulfate (POL) is a key component inducing time-dependent antagonism in freshwater luminescent bacteria,Vibrio qinghaiensissp.-Q67, exposed in the ternary mixture system of the ionic liquids, pesticide and antibiotics. However, the previous statement is limited to ternary and quaternary mixtures without considering situations such as the binary system. In order to prove the direct inducing of antagonism by POL in a more complete and systematic way, two categories of experiments (adding POL in non-antagonistic ternary system and decomposing antagonistic ternary system with POL into the binary system) have been conducted in this paper. The results showed that quaternary mixture systems (adding POL to non-antagonism ternary mixture, up verification) exhibit antagonistic action in a majority of rays, at some point in the experiment. However, by decomposing the antagonistic ternary mixtures with POL into binary mixtures (down verification), the combined toxicities of binary mixtures at all time points in the experiment are additive. Obviously, the POL has a significant contribution to antagonism only in the ternary and quaternary mixtures, but not in the binary mixtures. We can draw a new conclusion that the antagonism of the multi-component mixtures is induced by at least three components (including POL), with complex chemical interactions. Therefore, considering POL's influence of antagonism as an example, future environmental protection practitioners and academic researchers should construct more scenarios of mixtures when assessing the influences and reactions of certain chemicals causing pollutions.