An 8-year point-prevalence surveillance of healthcare-associated infections and antimicrobial use in a tertiary care teaching hospital in China.
An 8-year point-prevalence surveillance of healthcare-associated infections and antimicrobial use in a tertiary care teaching hospital in China.
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DOI：
10.1017/s0950268818002856
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发表时间：
2018-10-25
影响因子：
4.2
通讯作者：
Yang LQ
中科院分区：
文献类型：
--
作者：
Wu YL;Yang XY;Pan MS;Li RJ;Hu XQ;Zhang JJ;Yang LQ
医疗保健相关感染（HAI）是一个主要的全球性公共卫生问题，但在中国东部地区，关于HAI和抗菌药物使用的长期趋势的数据较少。本研究基于年度时点患病率调查，描述了2010年至2017年中国安徽省合肥市一家三级医疗教学医院HAI和抗菌药物使用的患病率和长期趋势。共纳入12505例住院患者，533例患者中记录了600例HAI，总患病率为4.26%，频率为4.80%。未发现HAI患病率在8年内呈上升或下降趋势的证据（趋势χ2 = 2.15，P = 0.143）。两组HAI患病率差异有统计学意义（χ2 = 21.14，P < 0.001）。重症监护病房的HAI发生率最高（24.36%），呼吸道感染占所有病例的62.50%，大肠埃希菌是最常见的病原体（16.67%）。抗菌药物使用率为44.13%，随时间推移呈逐渐下降趋势。应重视潜在的高危科室和HAI类型，进一步加强抗菌药物的合理使用。
Healthcare-associated infections (HAIs) are a major worldwide public-health problem, but less data are available on the long-term trends of HAIs and antimicrobial use in Eastern China. This study describes the prevalence and long-term trends of HAIs and antimicrobial use in a tertiary care teaching hospital in Hefei, Anhui, China from 2010 to 2017 based on annual point-prevalence surveys. A total of 12 505 inpatients were included; 600 HAIs were recorded in 533 patients, with an overall prevalence of 4.26% and a frequency of 4.80%. No evidence was found for an increasing or decreasing trend in prevalence of HAI over 8 years (trend χ2 = 2.15, P = 0.143). However, significant differences in prevalence of HAI were evident between the surveys (χ2 = 21.14, P < 0.001). The intensive care unit had the highest frequency of HAIs (24.36%) and respiratory tract infections accounted for 62.50% of all cases; Escherichia coli was the most common pathogen (16.67%). A 44.13% prevalence of antimicrobial use with a gradually decreasing trend over time was recorded. More attention should be paid to potential high-risk clinical departments and HAI types with further enhancement of rational antimicrobial use.