A Disintegrin and Metalloprotease (ADAM): Historical Overview of Their Functions.
A Disintegrin and Metalloprotease (ADAM): Historical Overview of Their Functions.
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DOI：
10.3390/toxins8040122
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发表时间：
2016-04-23
期刊：
影响因子：
4.2
通讯作者：
Zigrino P
中科院分区：
文献类型：
--
作者：
Giebeler N;Zigrino P
自从从蛇毒中发现第一个解整合素蛋白以及随后鉴定出与受精有关的哺乳动物膜锚定金属蛋白酶解整合素以来，近三十年的研究已经确定了这些家族的其他成员以及调节它们在细胞中表达和活性的几种生化机制。最重要的是，这些蛋白质的新体内功能已被认识，包括发育过程中的细胞分配、炎症反应的调节和癌症的发展。在这篇综述中，我们将概述解整合素和金属蛋白酶 (ADAM) 蛋白酶家族，重点介绍 ADAM 功能分析中的一些主要研究成果，这些成果强调了这些蛋白质多年来在生理和病理过程中的重要性。
Since the discovery of the first disintegrin protein from snake venom and the following identification of a mammalian membrane-anchored metalloprotease-disintegrin implicated in fertilization, almost three decades of studies have identified additional members of these families and several biochemical mechanisms regulating their expression and activity in the cell. Most importantly, new in vivo functions have been recognized for these proteins including cell partitioning during development, modulation of inflammatory reactions, and development of cancers. In this review, we will overview the a disintegrin and metalloprotease (ADAM) family of proteases highlighting some of the major research achievements in the analysis of ADAMs’ function that have underscored the importance of these proteins in physiological and pathological processes over the years.