DIFFERING LYMPHOKINE PROFILES OF FUNCTIONAL SUBSETS OF HUMAN CD4 AND CD8 T-CELL CLONES
DIFFERING LYMPHOKINE PROFILES OF FUNCTIONAL SUBSETS OF HUMAN CD4 AND CD8 T-CELL CLONES
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DOI：
10.1126/science.1681588
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发表时间：
1991-10-11
期刊：
影响因子：
56.9
通讯作者：
BLOOM, BR
中科院分区：
文献类型：
--
作者：
SALGAME, P;ABRAMS, JS;BLOOM, BR
通过分析麻风病患者的克隆细胞以及已知功能的T细胞克隆所产生的淋巴因子模式，对人类T细胞的功能亚群进行了描述。来自具有强细胞介导免疫的个体的CD4克隆主要产生干扰素 - γ，而那些增强抗体形成的克隆则产生白细胞介素 - 4。CD8细胞毒性T细胞分泌干扰素 - γ。白细胞介素 - 4由来自对麻风病免疫无反应个体的CD8 T抑制性克隆产生，并且发现它在体外抑制作用中是必需的。抗体形成和细胞介导免疫之间的经典相互关系以及对某些感染的抵抗力或易感性都可以通过淋巴因子产生模式不同的T细胞亚群来解释。
Functional subsets of human T cells were delineated by analyzing patterns of lymphokines produced by clones from individuals with leprosy and by T cell clones of known function. CD4 clones from individuals with strong cell-mediated immunity produced predominantly interferon-gamma, whereas those clones that enhanced antibody formation produced interleukin-4. CD8 cytotoxic T cells secreted interferon-gamma. Interleukin-4 was produced by CD8 T suppressor clones from immunologically unresponsive individuals with leprosy and was found to be necessary for suppression in vitro. Both the classic reciprocal relation between antibody formation and cell-mediated immunity and resistance or susceptibility to certain infections may be explained by T cell subsets differing in patterns of lymphokine production.