Heterologous interactions between NS1 proteins from different influenza A virus subtypes/strains
Heterologous interactions between NS1 proteins from different influenza A virus subtypes/strains
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不同甲型流感病毒亚型/毒株的 NS1 蛋白之间的异源相互作用
DOI：
10.1007/s11427-012-4335-6
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发表时间：
2012-06-01
影响因子：
9.1
通讯作者：
Li KangSheng
中科院分区：
文献类型：
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作者：
Li WeiZhong;Zhang Heng;Li KangSheng
流感病毒的非结构蛋白 1 (NS1) 在调节宿主免疫反应和促进病毒复制方面发挥着至关重要的作用。同型二聚体或寡聚体的形成对于 NS1 有效发挥其功能是必要的。在本研究中，发现A/shantou/602/06(H3N2)病毒(本文缩写为NS32)的NS1蛋白与A/shantou/169/06(H1N1)、A/Chicken/Guangdong/1/05(H5N1)和A/Quail/Hong Kong/G1/97(H9N2)(缩写为NS1)的NS1相互作用。 NS11、NS51 和 NS92 病毒，尽管 NS32 与 NS11、NS51 和 NS92 具有 17.4%–20.9% 的序列多样性。这表明来自不同甲型流感病毒亚型/毒株的 NS1 蛋白之间的异源相互作用可能是共同感染期间的常见事件。
Non-structural protein 1 (NS1) of the influenza virus plays a crucial role in modulating the host immune response and facilitating virus replication. The formation of a homodimer or an oligomer is necessary for NS1 to exert its function efficiently. In the present study, the NS1 protein from the A/Shantou/602/06(H3N2) virus (herein abbreviated as NS32) was found to interact with NS1 from A/Shantou/169/06(H1N1), A/Chicken/Guangdong/1/05(H5N1) and A/Quail/Hong Kong/G1/97(H9N2) (abbreviated as NS11, NS51 and NS92, respectively) viruses, although NS32 shares 17.4%–20.9% sequence diversity with NS11, NS51 and NS92. This indicates that the heterologous interactions between NS1 proteins from different influenza A virus subtypes/ strains may be a common event during co-infection.