PEPTIDE-SYNTHESIS .7. SOLID-PHASE SYNTHESIS OF CONOTOXIN-G1
PEPTIDE-SYNTHESIS .7. SOLID-PHASE SYNTHESIS OF CONOTOXIN-G1
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DOI：
10.1039/p19850002065
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发表时间：
1985-01-01
期刊：
影响因子：
--
通讯作者：
WARD, P
中科院分区：
文献类型：
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作者：
ATHERTON, E;SHEPPARD, RC;WARD, P
利用氟酰甲氧基羰基氨基酸和极性聚（二甲基丙烯酰胺）基载体，采用固相法合成了来自Conus geographus的神经毒素conotoxon G1。通过对半胱氨酸残基采用s -乙酰氨基甲基和s -t-丁基亚苯基的不同保护，选择性地形成了两个二硫桥。
The neurotoxin conotoxon G1 from Conus geographus has been synthesized by a solid-phase method using fluorenylmethoxycarbonylamino acids and a polar, poly(dimethylacrylamide)-based support. The two disulphide bridges were formed selectively by differential protection of cysteine residues using S-acetamidomethyl and S-t-butylsulphenyl groups.