Magnetic resonance monitoring of focused ultrasound/magnetic nanoparticle targeting delivery of therapeutic agents to the brain
Magnetic resonance monitoring of focused ultrasound/magnetic nanoparticle targeting delivery of therapeutic agents to the brain
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DOI：
10.1073/pnas.1003388107
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发表时间：
2010-08-24
影响因子：
11.1
通讯作者：
Wei, Kuo-Chen
中科院分区：
文献类型：
--
作者：
Liu, Hao-Li;Hua, Mu-Yi;Wei, Kuo-Chen
磁性纳米颗粒（MNP）的超顺磁性使它们能够被外部定位的磁体引导，并且还为MRI提供对比度。然而，它们在体内治疗CNS病理的治疗用途受到由于它们不能穿过生物屏障而导致的局部积累和保留不足的限制。聚焦超声和磁靶向的组合使用协同地递送治疗性MNP穿过血脑屏障以被动和主动地进入大脑。在体外和体内表征和评价治疗性MNP，并且使用MRI来监测和量化它们在体内的分布。该技术可用于正常大脑或肿瘤患者，并显著增加治疗性MNP在血脑屏障完整或受损的大脑中的沉积。协同靶向和图像监测是在MRI引导下将大分子化疗剂递送到CNS中的强大技术。
The superparamagnetic properties of magnetic nanoparticles (MNPs) allow them to be guided by an externally positioned magnet and also provide contrast for MRI. However, their therapeutic use in treating CNS pathologies in vivo is limited by insufficient local accumulation and retention resulting from their inability to traverse biological barriers. The combined use of focused ultrasound and magnetic targeting synergistically delivers therapeutic MNPs across the blood-brain barrier to enter the brain both passively and actively. Therapeutic MNPs were characterized and evaluated both in vitro and in vivo, and MRI was used to monitor and quantify their distribution in vivo. The technique could be used in normal brains or in those with tumors, and significantly increased the deposition of therapeutic MNPs in brains with intact or compromised blood-brain barriers. Synergistic targeting and image monitoring are powerful techniques for the delivery of macromolecular chemotherapeutic agents into the CNS under the guidance of MRI.