Cancer control related to stimulation of immunity by low-dose radiation
Cancer control related to stimulation of immunity by low-dose radiation
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DOI：
10.2203/dose-response.06-108.liu
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发表时间：
2007-01-01
期刊：
影响因子：
2.5
通讯作者：
Liu, Shu-Zheng
中科院分区：
文献类型：
--
作者：
Liu, Shu-Zheng
先前的研究表明，低剂量辐射（LDR）可以刺激动物和人类的免疫系统。本文综述了相关研究现状，为临床应用LDR预防和治疗癌症提供支持。研究表明，辐射引起的免疫活性变化遵循反j型曲线，即低剂量刺激和高剂量抑制。LDR对免疫的刺激涉及大多数抗癌参数，包括抗体形成、自然杀伤活性、干扰素和其他细胞因子的分泌以及其他细胞变化。动物实验表明，LDR能延缓肿瘤生长，减少肿瘤转移，抑制高剂量辐射引起的癌变。LDR对癌症控制的这些作用被发现与其对免疫的刺激有关。实验数据可以很好地解释LDR临床试验治疗癌症的疗效。
Previous studies showed that low dose radiation (LDR) could stimulate the immune system in both animal and human populations. This paper reviews the present status of relevant research as support to the use of LDR in clinical practice for cancer prevention and treatment. It has been demonstrated that radiation-induced changes in immune activity follows an inverse J-shaped curve, i.e., low dose stimulation and high dose suppression. The stimulation of immunity by LDR concerns most anticancer parameters, including antibody formation, natural killer activity, secretion of interferon and other cytokines as well as other cellular changes. Animal studies have revealed that LDR retards tumor growth, decreases cancer metastasis, and inhibits carcinogenesis induced by high dose radiation. These effects of LDR on cancer control were found to be related to its stimulation on immunity. The experimental data may well explain the efficacy of the clinical trial of LDR in the treatment of cancer.