The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis
The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis
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DOI：
10.1038/nm0296-175
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发表时间：
1996-02-01
期刊：
影响因子：
82.9
通讯作者：
Liew, FY
中科院分区：
文献类型：
--
作者：
McInnes, IB;AlMughales, J;Liew, FY
白细胞介素15 （IL-15）是一种具有白细胞介素2样活性的新型细胞因子。它也是一种有效的t淋巴细胞化学引诱剂。类风湿性关节炎（RA）是一种慢性炎症性疾病，其特征是滑膜中存在活化的T淋巴细胞、巨噬细胞和滑膜细胞。RA中t细胞活化的机制目前尚不清楚。我们报道了在类风湿性关节炎（RA）滑膜液中高浓度IL-15的存在，并通过免疫组织化学证实了其在滑膜衬里层中的表达。RA滑液被发现含有趋化活性，这部分归因于IL-15的存在。此外，在小鼠模型中，注射重组IL-15可诱导以T淋巴细胞为主的局部组织炎症浸润。滑膜液T淋巴细胞对IL-15有增殖反应，表明进入滑膜腔后对IL-15的持续反应是T细胞的一个特征，这些数据表明IL-15可以招募和激活进入滑膜的T淋巴细胞，从而促进RA的发病。
Interleukin 15 (IL-15) is a novel cytokine with interleukin-2-like activity. It is also a potent T-lymphocyte chemoattractant. Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by the presence of activated T lymphocytes, macrophages and synoviocytes in the synovial membrane. The mechanisms of T-cell activation in RA are currently unclear. We report the presence of high concentrations of IL-15 in rheumatoid arthritis (RA) synovial fluid and have demonstrated its expression in the synovial membrane lining layer by immunohistochemistry. RA synovial fluids were found to contain chemotactic activity, which was attributable in part to the presence of IL-15. Moreover, in a murine model, injection of recombinant IL-15 was found to induce a local tissue inflammatory infiltrate consisting predominantly of T lymphocytes. Synovial fluid T lymphocytes proliferate in response to IL-15, demonstrating that continued responsiveness to IL-15 is a feature of T cells after entry into the synovial compartment, These data suggest that IL-15 can recruit and activate T lymphocytes into the synovial membrane, thereby contributing to RA pathogenesis.