Is There a Future for AKT Inhibitors in the Treatment of Cancer?
Is There a Future for AKT Inhibitors in the Treatment of Cancer?
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DOI：
10.1158/1078-0432.ccr-16-0100
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发表时间：
2016-06-01
期刊：
影响因子：
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通讯作者：
Arteaga CL
中科院分区：
文献类型：
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作者：
Jansen VM;Mayer IA;Arteaga CL
An AKT inhibitor plus an antiestrogen exhibited no significant clinical activity in patients with ER+/HER2− breast cancer despite laboratory studies supporting an antitumor effect for both drugs combined. These results raise concerns about the development of AKT inhibitors in unselected patients whose tumors have unknown dependence on the PI3K/AKT pathway.
