Revealing the Synergistic Mechanism of Multiple Components in Compound Fengshiding Capsule for Rheumatoid Arthritis Therapeutics by Network Pharmacology
Revealing the Synergistic Mechanism of Multiple Components in Compound Fengshiding Capsule for Rheumatoid Arthritis Therapeutics by Network Pharmacology
复制标题
网络药理学揭示复方风湿定胶囊治疗类风湿关节炎多成分协同机制
DOI：
10.2174/1566524019666190405094125
复制
发表时间：
2019-01-01
影响因子：
2.5
通讯作者：
Shan, Ling-ling
中科院分区：
文献类型：
--
作者：
Duan, Hong;Zhai, Ke-feng;Shan, Ling-ling
背景资料：复方风湿定胶囊是由八角枫、白芷、徐长卿、甘草等中草药制成的中药制剂。CFC被广泛用于治疗类风湿性关节炎的临床治疗。方法：为探讨CFC的协同作用机制，采用网络药理学方案，筛选与CFC组分相关的作用靶点。本研究分析了PubMed数据库中水杨苷、丹皮酚、甘草苷和欧前胡素的作用靶点，探讨了它们在类风湿关节炎、颈神经痛和坐骨神经痛相关疾病中的潜在药理作用靶点。代谢途径增强的结果表明，CFC的化学成分中断了许多免疫相关的途径，从而参与机体的免疫调节，起到治疗风湿病的作用。总的来说，CFC具有细胞凋亡，氧化应激调节和抗炎作用，积累其临床应用服务于类风湿arthritis.Conclusion：总之，我们的研究结果从目前的研究发现，通过利用网络药理学机制的四个有效成分用于治疗风湿病的系统的理论方法侦察和紧凑，表明足够的潜在药物靶点与CFC抗风湿病。这些有趣的发现为进一步的体内外研究复方活性成分抗风湿的机制提供了依据。
Background: Compound Fengshiding capsule (CFC), is a Chinese formulation from herbal origin including Alangium platanifolium, Angelicae dahurica, Cynanchum paniculatum and Glycyrrhiza uralensis. CFC is widely used as clinical therapy against rheumatoid arthritis. However, its exact mechanism of action has not been explored yet.Methods: In order to explore the synergistic mechanism of CFC, we designed a study adopting network pharmacology scheme to screen the action targets in relation to the CFC components. The study analyses target facts of salicin, paeonol, liquiritin and imperatorin from PubMed database, and explores the potential pharmacological targets of rheumatoid arthritis, cervical neuralgia and sciatica related diseases for their interaction.Results: The results of boosted metabolic pathway showed that the chemical components of CFC interrupted many immune-related pathways, thus participating in immunity regulation of the body and playing a role in the treatment of rheumatism. Collectively, CFC has apoptotic, oxidative stress modulatory and anti-inflammatory effects that accumulatively serve for its clinical application against rheumatoid arthritis.Conclusion: Conclusively, our findings from present study reconnoiters and compacts systematic theoretical approach by utilizing the network pharmacology mechanism of four effective components for the treatment of rheumatism indicating sufficient potential drug targets associated with CFC against rheumatism. These interesting findings entreaties for further in vitro and in vivo studies on the mechanism of compound active ingredient against rheumatism.