A new carbohydrate-based wound dressing fibre with superior absorption and antimicrobial potency
A new carbohydrate-based wound dressing fibre with superior absorption and antimicrobial potency
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DOI：
10.1016/j.carbpol.2013.10.058
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发表时间：
2014-01-30
影响因子：
11.2
通讯作者：
Edward-Jones, V.
中科院分区：
文献类型：
--
作者：
Miraftab, M.;Masood, R.;Edward-Jones, V.
如果没有充分管理，大量渗出的伤口可能会导致感染和不必要的创伤。从事高吸收银敷料的生产和营销的制造商除了强调其敷料的高吸收外，还热衷于强调其产品对各种病原体（包括MRSA）的有效抗菌能力。但是，几乎没有或没有可靠的报道，关于敷料中所需的最少但有效的白银，以消除细菌传播和生长，或者随着时间的推移而有效地释放了敷料中的白银。本文引入了一种由基于多糖的聚合物制成的新型混合生物材料纤维，具有内置的凝胶和吸收大量伪渗出液的能力。此外，据报道，新纤维的银色最多降低了六倍的银色，比通常在银色敷料中使用的银色少六倍，并且显示出非常缓慢的释放速度，同时随着时间的推移与已知的革兰氏正面，革兰氏阴性微生物（包括）保持全部效力MRSA。该论文得出的结论是，与Acticoat AA和Aquacel Ag相比，开发的杂种纤维具有持久的抗菌和胶凝特性，即两种市售的银敷料。 （c）2013 Elsevier Ltd.保留所有权利。
Heavily exudating wounds can lead to infection and unnecessary trauma if they are not adequately managed. Manufacturers involved in production and marketing of high absorption silver dressings, besides emphasising high absorptions of their dressings are keen to highlight potent antimicrobial abilities of their products against all kinds of pathogens including MRSA. However, there are little or no credible reports on minimal but potent quantities of silver needed in a dressing to eliminate bacteria spread and growth or how effectively the silver within a dressing is released over time. This paper introduces a new hybrid biomaterial fibre made from polysaccharide-based polymers with inbuilt ability to gel and absorb large quantities of pseudo exudates. Furthermore, it will be reported that the new fibre carries up to six times less silver than it is conventionally used in silver dressings and displays a very slow rate of release whilst maintaining full potency over time against known Gram positive, Gram negative micro-organisms including MRSA. The paper concludes that the developed hybrid fibre has long lasting antimicrobial and gelling properties comparable, if not better, than Acticoat AA and Aquacel Ag, two commercially available silver dressings. (C) 2013 Elsevier Ltd. All rights reserved.