A regulatory role for the memory B cell as suppressor-inducer of feedback control.
A regulatory role for the memory B cell as suppressor-inducer of feedback control.
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DOI：
10.1084/jem.157.2.547
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发表时间：
1983-02-01
影响因子：
15.3
通讯作者：
Thomas, D B
中科院分区：
文献类型：
--
作者：
Kennedy, M W;Thomas, D B
提出了抗原应答B细胞在体内次级应答过程中作为反馈控制的抑制剂-诱导剂的调节作用。在对胸腺依赖性抗原致敏的记忆细胞从一个辐射宿主到另一个辐射宿主的双重过继转移中，抗原特异性抑制子在初级受体中的关键时间后产生，能够完全消除次级抗半抗原应答。荧光激活细胞分选仪中的阳性细胞选择证实抑制由Lyt-2+ T细胞介导;然而，阳性选择的B细胞也具有抑制性，并且能够以载体特异性方式诱导抑制子：半抗原在载体致敏群体中诱导抑制子，而Bcarrier在半抗原-载体群体中诱导抑制子。在原代宿主中抗体应答的高峰期，记忆B细胞及其后代由于其内在的抑制-诱导活性而不能进一步分化为浆细胞，但这种自身调节回路可以通过过继转移至载体致敏的X射线照射受体而被切断。
A regulatory role is proposed for the antigen-responsive B cell, as suppressor-inducer of feedback control during the secondary response in vivo. In a double adoptive transfer of memory cells primed to a thymus- dependent antigen from one irradiated host to another, antigen-specific suppressors are generated after a critical time in the primary recipient, able to entirely ablate a secondary anti-hapten response. Positive cell selection in the fluorescence-activated cell sorter confirmed that suppression was mediated by an Lyt-2+ T cell; however, positively selected B cells were also inhibitory and able to induce suppressors in a carrier-specific manner: Bhapten induced suppressors in a carrier-primed population, and Bcarrier induced suppressors in a hapten-carrier population. At the peak of the antibody response in the primary host, memory B cells and their progeny were unable to differentiate further to plasma cells due to their intrinsic suppressor- inducer activity, but this autoregulatory circuit could be severed by adoptive transfer to carrier-primed, X-irradiated recipients.