Insulin metabolism is altered in migraineurs: A new pathogenic mechanism for migraine?
Insulin metabolism is altered in migraineurs: A new pathogenic mechanism for migraine?
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DOI：
10.1111/j.1526-4610.2007.00719.x
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发表时间：
2007-11-01
期刊：
影响因子：
5
通讯作者：
Beghi, Ettore
中科院分区：
文献类型：
--
作者：
Cavestro, Cinzia;Rosatello, Annalisa;Beghi, Ettore
背景。-偏头痛是一种复杂的生化功能障碍，归因于三叉神经和下丘脑通路的障碍。葡萄糖代谢受损已在偏头痛中报道，但数据很少且不一致。主要目的是验证偏头痛患者是否有葡萄糖和胰岛素代谢异常。我们还研究了血糖和胰岛素之间的相关性，以及胰岛素水平和偏头痛严重程度之间的相关性。包括患有偏头痛或除偏头痛以外的头痛的患者和健康志愿者。禁食12小时后，所有人都进行了一般血液检查和标准口服葡萄糖耐量测试，并测量了血糖和胰岛素。结果。-在6个月的时间里，我们招募了84名偏头痛患者（73名女性，11名男性），25名非偏头痛患者（20名女性，5名男性）和26名健康对照（24名女性，2名男性）。多变量分析证实两组间血糖水平有显著差异（P
Background.-Migraine is a complex biochemical dysfunction attributed to a disorder of the trigeminal and hypothalamic pathways. Impairment of glucose metabolism has been reported in migraine, but data are scanty and inconsistent.Objective.-The main aim was to verify whether migraineurs have abnormalities of the glucose and insulin metabolism.We also studied correlations between blood glucose and insulin and between insulin levels and migraine severity.Patients and methods.-Patients with migraine or headache other than migraine, and healthy volunteers were included. All had general blood tests and a standard oral glucose tolerance test after a 12-hour fast, and glucose and insulin were measured.Results.-Over a 6-month period, we recruited 84 migraineurs (73 women, 11 men), 25 patients with nonmigraine headache (20 women, 5 men), and 26 healthy controls (24 women, 2 men). Multivariate analysis confirmed a significant difference between groups for glucose levels (P