Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex.
Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex.
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DOI：
10.1016/j.neuroscience.2015.07.041
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发表时间：
2016-05-03
期刊：
影响因子：
3.3
通讯作者：
Tye KM
中科院分区：
文献类型：
--
作者：
Felix-Ortiz AC;Burgos-Robles A;Bhagat ND;Leppla CA;Tye KM
基底外侧杏仁核（BLA）和内侧前额叶皮层（mPFC）调节焦虑和社会行为。然而，从BLA到mPFC的直接投射是否在这些行为中发挥功能作用仍有待阐明。在行为分析中，我们使用光遗传学方法在行为小鼠中激活或抑制BLA输入到mPFC，以评估焦虑样行为和社会互动。通道视紫红质-2 （ChR2）介导的BLA输入到mPFC的激活在高海拔迷宫和空旷场试验中产生焦虑效应，而盐视紫红质（NpHR）介导的抑制产生焦虑效应。此外，BLA-mPFC通路的激活减少了居民-入侵者测试中的社会互动，而抑制促进了社会互动。这些结果建立了BLA-mPFC通路活动与焦虑和社会行为双向调节之间的因果关系。
The basolateral amygdala (BLA) and the medial prefrontal cortex (mPFC) modulate anxiety and social behaviors. It remains to be elucidated, however, whether direct projections from the BLA to the mPFC play a functional role in these behaviors. We used optogenetic approaches in behaving mice to either activate or inhibit BLA inputs to the mPFC during behavioral assays that assess anxiety-like behavior and social interaction. Channelrhodopsin-2 (ChR2)-mediated activation of BLA inputs to the mPFC produced anxiogenic effects in the elevated-plus maze and open-field test, whereas halorhodopsin (NpHR)-mediated inhibition produced anxiolytic effects. Furthermore, activation of the BLA-mPFC pathway reduced social interaction in the resident-intruder test, whereas inhibition facilitated social interaction. These results establish a causal relationship between activity in the BLA-mPFC pathway and the bidirectional modulation of anxiety and social behaviors.