Strong dependence of the nano-bio interactions on core morphology and layer composition of ultrasmall nanostructures
Strong dependence of the nano-bio interactions on core morphology and layer composition of ultrasmall nanostructures
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DOI：
10.1063/1.5115192
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发表时间：
2019-09-14
影响因子：
4.4
通讯作者：
Hassan, Sergio A.
中科院分区：
文献类型：
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作者：
Hassan, Sergio A.
纳米颗粒与蛋白质、细胞和组织之间的相互作用，即所谓的纳米生物相互作用，取决于纳米颗粒的大小和形状，以及纳米颗粒包覆层的特性，如密度、厚度和化学组成。通过计算机模拟研究了纳米膜相互作用对超微纳米结构设计参数的依赖关系。这里考虑的是由裸露的磁铁矿或钝化金组成的球、板、环、棒、管和螺旋，它们与带电或两性离子膜相互作用。分析揭示了纳米生物行为对形状、大小和层组成的各种数量的强烈依赖，包括结合模式和亲和力。这种敏感性可以被用来设计优先与膜结合的纳米结构，或者稳定或破坏膜结构的完整性。该方法通用性强，不局限于超微区域，可用于其他纳米生物相互作用的系统研究。讨论了NPs在细胞和组织中的分布(生物分布)以及被动和主动跨膜运输的意义，这两个过程都是生物医学中的重要过程。
The interactions between nanoparticles (NPs) and proteins, cells, and tissues, broadly known as nano-bio interactions, depend on the NP size and shape and on the characteristics of the NP coating layer, such as density, thickness, and chemical makeup. The dependence of nano-membrane interactions on the design parameters of ultrasmall nanostructures is studied by computer simulations. Considered here are spheres, plates, rings, rods, tubes, and helices made up of either bare magnetite or passivated gold, interacting with charged or zwitterionic membranes. The analysis reveals a strong dependence on shape, size, and layer composition of various quantities that characterize the nano-bio behavior, including binding modes and affinities. This sensitivity can be exploited to design nanostructures that bind preferentially to membranes or that stabilize or disrupt membrane structural integrity. The method used here is general and not limited to the ultrasmall regime, so it can be adopted to study other nano-bio interactions systematically. The implications for the distribution of NPs in cells and tissues (biodistribution) and for passive and active transmembrane transport are discussed, both important processes in biomedicine.