Expression of hepatocyte growth factor/scatter factor receptor in IUGR fetuses' placentas:: An immunohistochemical analysis
Expression of hepatocyte growth factor/scatter factor receptor in IUGR fetuses' placentas:: An immunohistochemical analysis
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DOI：
10.1159/000085079
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发表时间：
2005-01-01
影响因子：
2.2
通讯作者：
Ayhan, A
中科院分区：
文献类型：
--
作者：
Baykal, C;Güler, G;Ayhan, A
目的：目的探讨肝细胞生长因子（HGF）受体c-met在胎儿宫内发育迟缓（IUGR）胎盘中的表达状况。材料与方法：收集正常妊娠晚期及IUGR合并症孕妇分娩时的胎盘。超声评估胎儿出生体重，并将低于胎龄第五百分位数的胎盘纳入研究组。18例IUGR胎儿和6例无并发症妊娠进行了研究。胎盘的组织切片用免疫化学方法评价c-met的表达状态。结果如下：研究组18例中有17例（94.4%）c-met过表达，而对照组仅为16.7%（1/6）（p <0.0001）。两组间c-met表达程度有显著的统计学差异。结论：c-met是人胎盘细胞膜上重要的受体。胎盘形成过程中HGF与其受体c-met相互作用的失调可能是胎盘功能受损导致胎儿生长迟缓的原因。版权所有（c）2005 S. Karger AG，巴塞尔。
Objective: We aimed to evaluate the expression status of c-met, receptor for the hepatocyte growth factor (HGF), in the placentas of intrauterine growth retardation (IUGR) fetuses. Materials and Methods: Placentas were obtained during delivery from both third trimester normal and IUGR complicated pregnancies. Ultrasonographic estimation of fetal birth weight has been done and placentas of those under the fifth percentile for their gestational ages were enrolled in the study group. Eighteen fetuses with IUGR and 6 uncomplicated pregnancies were subjected to the study. Histological sections from placentas were immunohistochemically evaluated for the expression status of c-met. Results: Seventeen of the eighteen patients (94.4%) in the study group were found to have overexpression of the c-met while this figure was only 16.7% (1/6) in the control group (p < 0.0001). There was a strong statistically significant difference between the two groups regarding degree of c-met expression. Conclusion: Our present findings suggest that c-met is an important cell membrane receptor in human placenta. Deregulation of the interaction between HGF and its receptor c-met during placentation may be the cause responsible for the growth retardation of the fetus due to the impaired placental functions. Copyright (c) 2005 S. Karger AG, Basel.