Childhood lymphoma resembling “burkitt tumor” in the United States
Childhood lymphoma resembling “burkitt tumor” in the United States
复制标题
儿童淋巴瘤在美国重新组装“伯基特瘤”
作者：
G. O'conor;H. Rappaport;E.Bertram Smith
东非和西非的医疗中心报告说，非白血病性淋巴瘤的相对发病率异常高。~, 5, *， 15来自这些地区的有限发病率数据表明，其发病率至少是美国的5倍。赤道非洲儿童的绝大多数淋巴瘤在临床、大体解剖和组织学特征上相似，这导致他们被称为“伯基特瘤”，或者被称为“非洲淋巴瘤”或“荒谬”淋巴瘤。这些名称暗示着一种非洲特有的疾病，事实上，许多研究人员认为，这种疾病的组织病理学特征是在非洲某些地理限制之外很少见到的。因此，有些人认为，这些淋巴瘤是由气候因素决定的然而，我们的信念和经验仍然是，所谓的“伯基特瘤”并非非洲所特有。相反，它代表了非白血病儿童淋巴瘤的预期发病率的显著变化，这种疾病在其他地方相对罕见。为了支持这一点，我们从武装部队病理研究所的附加材料中报告了20例美国儿童非白血病淋巴瘤的例子。这些病例表现出的生物学行为和组织学外观与非洲报告的大多数病例相似或相同。
EDICAL CENTERS IN EAST AND WEST AFRICA M have reported an unusually high relative frequency of non-leukemic lymphomas in ~h i ld ren .~ , 5 , * , 15 Limited incidence figures from these same areas indicate a rate at least 5 times that in the United The overwhelming majority of these lymphomas in children in equatorial Africa are similar in their clinical, gross anatomical and histological features and this has resulted in their identification by eponym-‘‘the Burkitt tumor”-or by such terms as “the African lymphoma” or the “absurd” lymphoma. These names imply a disease unique to Africa and, indeed, a number of investigators consider the histopathology specific for an entity rarely seen beyond certain geographic limitations in Africa.12v By some, therefore, these lymphomas are thought to be determined by climatic factors.2 It continues to be our belief and experience, however, that the so called “Burkitt tumor” is not peculiar to Africa. Rather, i t represents a striking variation in expected incidence of non-leukemic childhood lymphoma, a disease relatively uncommon e1~ewhere.l~ In support of this we are reporting from the accessioned material at the Armed Forces Institute of Pathology 20 selected examples of non-leukemic lymphoma in American children. These displayed a biological behavior and a histological appearance similar or identical to the majority of those cases reported from Africa.