The effects of exposure to cytosine arabinoside upon the proliferation of leukemia colony forming units in vitro.
The effects of exposure to cytosine arabinoside upon the proliferation of leukemia colony forming units in vitro.
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暴露于阿糖胞苷对体外白血病集落形成单位增殖的影响。
DOI：
10.1002/mpo.2950100714
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Preisler,HD
中科院分区：
文献类型：
--
作者：
Preisler,HD
测定急性髓细胞白血病细胞和慢性髓细胞白血病细胞的白血病集落形成单位对体外暴露于阿糖胞苷的敏感性。不同患者白血病细胞的敏感性存在显著差异。通过同时测量白血病克隆原细胞对3 H-TdR的敏感性，可以区分对阿糖胞苷的代谢和细胞周期动力学抗性。
The sensitivity of leukemic colony forming units to exposure to cytosine arabinoside in vitro was measured for both acute myelocytic leukemia cells and for chronic myelocytic leukemia cells. There was significant variability in the sensitivity of the leukemic cells of different patients. By simultaneous measurement of the sensitivity of leukemic clonogenic cells to3H‐TdR one can distinguish between metabolic and cell cycle kinetic resistance to cytosine arabinoside.