Assessment of the usefulness of helium-oxygen maximal expiratory flow curves in epidemiologic studies of lung disease in children.
Assessment of the usefulness of helium-oxygen maximal expiratory flow curves in epidemiologic studies of lung disease in children.
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评估氦氧最大呼气流量曲线在儿童肺部疾病流行病学研究中的有用性。
DOI：
10.1164/ajrccm/136.4.834
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Speizer,FE
中科院分区：
文献类型：
--
作者：
Redline,S;Tager,IB;Castile,RG;Weiss,ST;Barr,M;Speizer,FE
最大呼气气流（DD）的密度依赖性已被用于成人早期阻塞性气道疾病（OAD）的检测。DD是否可以作为确定儿童OAD危险因素的流行病学工具尚不清楚。在133名8至23岁儿童的人群样本中，我们计算了50%和25%肺活量时的密度依赖性（dd50和DD25）（在每个肺容量下呼吸氦氧和空气混合物的最大呼气流量之间的比率）和等流量（Vlao）（肺体积，以肺活量的百分比表示，在此情况下呼吸每种气体混合物的最大流量相等）。使用低温过度通气测量气道反应性，并通过问卷调查获得健康和家庭信息。DD50、DD25、Viso的平均水平（±SD）分别为：1.49±0.14、1.37±0.18、10.7±10%。非特异性支气管高反应性患儿dd50随年龄的增长明显增高（p < 0.05），而非特异性支气管高反应性患儿dd50明显降低（1.42±0.14 vs 1.52±0.13,p < 0.01）。近期有上呼吸道疾病（URI）病史的儿童dd50也显著降低（p < 0.01）。DD与哮喘史、个人吸烟史、父母吸烟史或婴儿期呼吸系统疾病史均无显著相关性。在90名受试者的子样本中评估了dd50的再现性，其中两次调查间隔1年测量了DD。dd50水平的年相关性为0.25 (p < 0.05)， FEF25-75水平的年相关性为0.71 （p < 0.001）。在基于人群的研究中，DD测试的流行病学有用性似乎受到这些测试固有的技术和生物学变异性的限制。此外，与DD降低相关的暴露也与FEF25-75的降低相关，这是一种更容易获得和更可重复的测量方法。
Density dependence of maximal expiratory air flow (DD) has been used in adults as a test of early obstructive airway disease (OAD). Whether DD is useful as an epidemiologic tool to identify childhood risk factors for OAD is not known. In a population-based sample of 133 children 8 to 23 yr of age, we calculated density dependence at 50 and 25% of vital capacity (DD50and DD25) (the ratios between maximal expiratory flow rates breathing helium-oxygen and air gas mixtures at each of these lung volumes), and the volume of isoflow (Vlao) (the lung volume, expressed as a percentage of vital capacity, at which maximal flow rates when breathing each gas mixture are equal), measured airway responsiveness using eucapnic hyperventilation with cold air, and obtained health and household information with questionnaires. Mean levels (± SD) of DD50, DD25, and Viso were: 1.49 ± 0.14, 1.37 ± 0.18, and 10.7 ± 10%. The DD50significantly increased with age in these growing children (p < 0.05), but DD50was found to be significantly lower (1.42 ± 0.14 versus 1.52 ± 0.13; p < 0.01) among children with nonspecific bronchial hyperresponsiveness. The DD50also was significantly reduced among children with a history of a recent upper respiratory tract illness (URI) (p < 0.01). There were no significant associations of DD with history of asthma, personal smoking, parental smoking, or respiratory illness during infancy. The reproducibility of DD50was assessed on a subsample of 90 subjects in whom DD was measured during 2 surveys 1 yr apart. The year-to-year correlation in level of DD50was 0.25 (p < 0.05), in contrast with a correlation of 0.71 (p < 0.001) for FEF25-75. The epidemiologic usefulness of tests of DD in population-based studies appeared to be limited by the technical and biologic variability inherent in these tests. Furthermore, exposures that were associated with reductions in DD also were associated with reductions In FEF25-75, a more easily obtained and more reproducible measurement.
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影响因子：
9.6
作者：
R. Zeck;N. Solliday;L. Celić;D. Cugell
通讯作者：
D. Cugell
流量限制的主要部位和劳力后哮喘的机制。
DOI：
10.1152/jappl.1977.42.5.746
发表时间：
1977
期刊：
Journal of applied physiology: respiratory, environmental and exercise physiology
影响因子：
--
作者：
E. Mcfadden;R. Ingram;R. L. Haynes;J. Wellman
通讯作者：
J. Wellman
上呼吸道病毒感染对小气道的长期影响。
DOI：
10.1016/0002-9343(72)90079-4
发表时间：
1972
期刊：
The American journal of medicine
影响因子：
--
作者：
J. Picken;D. Niewoehner;E. Chester
通讯作者：
E. Chester
评估空气与氦氧流量曲线作为流行病学筛查测试。
影响因子：
9.6
作者：
Knudson,RJ;Bloom,JW;Kaltenborn,WT;Burrows,B;Lebowitz,MD
通讯作者：
Lebowitz,MD
影响因子：
39.2
作者：
LITTLE, JW;HALL, WJ;SPEERS, DM
通讯作者：
SPEERS, DM