Antidepressant medication use and risk of persistent pulmonary hypertension of the newborn
Antidepressant medication use and risk of persistent pulmonary hypertension of the newborn
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DOI：
10.1002/pds.1710
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发表时间：
2009-03-01
影响因子：
2.6
通讯作者：
Platt, Richard
中科院分区：
文献类型：
--
作者：
Andrade, Susan E.;McPhillips, Heather;Platt, Richard
目的了解新生儿持续性肺动脉高压（PPHN）的患病率母亲在妊娠晚期暴露于抗抑郁药的婴儿与母亲在妊娠晚期未暴露于抗抑郁药的婴儿的患病率相比，治疗学研究。查明了1996年1月1日至2000年12月31日期间在医院分娩的妇女。管理数据库用于识别母亲在妊娠晚期接受抗抑郁药的足月婴儿和母亲在妊娠晚期未接受抗抑郁药的未暴露婴儿。住院数据被用来确定诊断或程序代码可能指示PPHN.Results在1104婴儿暴露于抗抑郁药在妊娠晚期和匹配的样本1104未暴露的婴儿，五个婴儿被归类为有PPHN的专家评审。在妊娠晚期母亲暴露于选择性5-羟色胺再摄取抑制剂（SSRIs）的婴儿中，PPHN的患病率为2.14/1000（95%置信区间（CI）0.26，7.74），而母亲未接触的婴儿的患病率为2.72/1000结论未发现妊娠晚期使用SSRI与PPHN之间存在相关性。本研究的局限性，包括确诊病例数量少，表明可能需要在这一领域进行进一步研究。版权所有（C）2009约翰威利父子有限公司
Purpose To determine the prevalence of persistent pulmonary hypertension of the newborn (PPHN) among infants whose mothers were exposed to antidepressants in the third trimester of pregnancy compared to the prevalence among infants whose mothers were not exposed to antidepressants in the third trimester.Methods A retrospective study was conducted using the automated databases of four health plans participating in the HMO Research Network Center for Education and Research on Therapeutics. Women who delivered an infant in a hospital from I January 1996 through 31 December 2000 were identified. The administrative databases were used to identify full-term infants whose mothers received an antidepressant during the third trimester of pregnancy and unexposed infants whose mothers did not receive an antidepressant during the third trimester. Hospitalization data were used to identify diagnoses or procedure codes potentially indicative of PPHN.Results Among 1104 infants exposed to antidepressants in the third trimester and a matched sample of 1104 unexposed infants, five infants were classified by the expert reviewers as having PPHN. Among those infants whose mothers were exposed to selective serotonin reuptake inhibitors (SSRIs) in the third trimester, the prevalence of PPHN was 2.14 per 1000 (95% confidence interval (CI) 0.26, 7.74), while the prevalence among infants whose mothers were not exposed was 2.72 per 1000 (95%CI 0.56, 7.93).Conclusions We did not find an association between SSRI use in late pregnancy and PPHN. Limitations of the present study, including the small number of confirmed cases, suggest further research in this area may be warranted. Copyright (C) 2009 John Wiley & Sons, Ltd.