Auditory risk of hyperbilirubinemia in term newborns: A systematic review
Auditory risk of hyperbilirubinemia in term newborns: A systematic review
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DOI：
10.1016/j.ijporl.2013.03.029
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发表时间：
2013-06-01
影响因子：
1.5
通讯作者：
Daniel, Sam J.
中科院分区：
文献类型：
--
作者：
Akinpelu, Olubunmi Victoria;Waissbluth, Sofia;Daniel, Sam J.
目的：高水平的未结合胆红素与神经元损伤有关。听觉脑核团和下丘通常是脑干的第一部分，通常会导致听力异常。对临床研究进行系统回顾，以评估高胆红素血症对足月新生儿听力的影响，以显示听力功能和胆红素水平之间的关系以及治疗效果。方法：通过电子数据库奥维德MEDLINE，奥维德MEDLINE过程中，Embase，PubMed和科克伦图书馆的搜索，确定合格的研究。获得的文献由2名作者使用纳入标准进行独立审查，以确定合格的研究。检索仅限于1970年至2010年期间发表的英文、法文和西班牙文文章。数据包括研究类型、患者数量、胆红素水平、高胆红素血症标准、听力评估方法、听力评估时间和结果measures.Results：纳入的19篇文章显示了关于听力测试时间和高胆红素血症标准的异质性。初始测试时听力损失的发生率范围为13.2-83.3%，3个月随访时为6.7-14.3%。五项研究表明，听力损失的发病率随着血清bilirin.Conclusions水平的增加而上升：高胆红素血症导致听力评估异常的足月新生儿高达83.3%。随着血清胆红素水平的升高，观察到更大的听力异常。高胆红素血症的治疗导致听力损失的发生率显著降低。(C)2013爱思唯尔爱尔兰有限公司版权所有。
Objectives: High levels of unconjugated bilirubin have been associated with neuronal damage. The auditory brain nuclei and the inferior colliculi are often the first part of the brainstem to be involved, often leading to hearing abnormalities. A systematic review of clinical studies was conducted to evaluate the effect of hyperbilirubinemia on hearing in term newborns, to show the relationship between hearing function and bilirubin levels as well as the effect of treatment.Methods: Eligible studies were identified through searches of electronic databases Ovid MEDLINE, Ovid MEDLINE In-Process, Embase, PubMed and The Cochrane Library. Articles obtained were independently reviewed by 2 authors using inclusion criteria to identify eligible studies. The search was restricted to articles written in English, French and Spanish and published between 1970 and 2010. Data extracted included study type, number of patients, bilirubin levels, hyperbilirubinemia criteria, hearing assessment methods, time of hearing assessment and outcome measures.Results: The nineteen articles included showed heterogeneity regarding the time of hearing test and hyperbilirubinemia criteria. The incidence of hearing loss at initial testing ranged between 13.2-83.3% and 6.7-14.3% at 3 months follow-up. Five studies showed a rising incidence of hearing loss with increasing levels of serum bilirubin.Conclusions: Hyperbilirubinemia resulted in abnormal hearing assessment in up to 83.3% of term newborns. Greater hearing abnormalities were observed with rising serum bilirubin levels. Treatment of hyperbilirubinemia led to a considerable decrease in the incidence of hearing loss. (C) 2013 Elsevier Ireland Ltd. All rights reserved.