Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons
Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons
复制标题
DOI：
10.1016/0006-8993(92)91597-8
复制
发表时间：
1992-08
期刊：
影响因子：
2.9
通讯作者：
Yoshifumi Watanabe;E. Gould;B. McEwen
中科院分区：
文献类型：
--
作者：
Yoshifumi Watanabe;E. Gould;B. McEwen
海马体很容易受到伤害，如短暂的缺血和重复刺激，以及反复暴露于外源性糖皮质激素。这项研究调查了重复的心理应激源--束缚对CA3锥体神经元的影响，这些神经元容易受到重复刺激的损伤。每日重复束缚应激21d，CA3区锥体神经元顶端树突萎缩，而基底区CA3树突无明显变化。接受这种治疗的大鼠是健康的，在21天内表现出对糖皮质激素应激反应的一定适应；然而，应激使体重增加减少了14%，肾上腺重量相对于体重增加了20%。研究结果与肾上腺类固醇和兴奋性氨基酸的可能作用有关。
The hippocampus is vulnerable to the damaging actions of insults such as transient ischemia and repetitive stimulation, as well as repeated exposure to exogenous glucocorticoids. This study investigated effects of a repeated psychological stressor, restraint, on the CA3 pyramidal neurons which are vulnerable to damage by repetitive stimulation. Repeated daily restraint stress for 21 days caused apical dendrites of CA3 pyramidal neurons to atrophy, while basal CA3 dendrites did not change. Rats undergoing this treatment were healthy and showed some adaptation of the glucocorticoid stress response over 21 days; however, stress reduced body weight gain by 14% and increased adrenal weight relative to body weight by 20%. Results are discussed in relation to the possible role of adrenal steroids and excitatory amino acids.