High resolution imaging of the intracranial vessel wall at 3 and 7 T using 3D fast spin echo MRI
High resolution imaging of the intracranial vessel wall at 3 and 7 T using 3D fast spin echo MRI
复制标题
DOI：
10.1007/s10334-016-0531-x
复制
发表时间：
2016-06-01
影响因子：
2.3
通讯作者：
Saloner, David
中科院分区：
文献类型：
--
作者：
Zhu, Chengcheng;Haraldsson, Henrik;Saloner, David
颅内血管壁的高分辨率MRI为颅内血管疾病的评估提供了重要的见解。本研究旨在通过定制的翻转角度序列设计，完善3 T和7 T时颅内血管壁成像的高分辨率3D MRI技术，并探讨它们的比较能力。11例颅内动脉疾病患者（4例动脉粥样硬化斑块，6例动脉瘤和1例可逆脑血管收缩综合征）在Gd造影剂注射前后分别使用3D T(1)加权快速自旋回波序列（SPACE）在3和7 T下成像。量化血管壁/腔对比度（CRwall-lumen）、对比度增强比（ER）和血管壁清晰度。两名经验丰富的放射科医生对图像质量进行了0-5分的评估。3和7t均具有高分辨率（标称各向同性0.5 mm）和全脑覆盖的良好图像质量。CRwall-lumen和ER测量值具有可比性（p < 0.05）。与3t相比，7t图像明显更清晰（清晰度：2.69 +/- 0.50 vs. 1.88 +/- 0.53 mm(-1), p < 0.001），图像质量更高（阅读器1评分：3.5 +/- 1.1 vs. 2.4 +/- 1.1, p = 0.002）。3d T(1)加权SPACE可用于颅内血管壁评估3 T和7t， 7t提供明显更好的图像质量，提高诊断的置信度。
High resolution MRI of the intracranial vessel wall provides important insights in the assessment of intracranial vascular disease. This study aims to refine high resolution 3D MRI techniques for intracranial vessel wall imaging at both 3 and 7 T using customized flip angle train design, and to explore their comparative abilities.11 patients with intracranial artery disease (four atherosclerotic plaques, six aneurysms and one reversible cerebral vasoconstriction syndrome) were imaged at 3 and 7 T with a 3D T (1)-weighted fast-spin-echo sequence (SPACE) both pre and post Gd contrast injection. Wall to lumen contrast ratio (CRwall-lumen), contrast enhancement ratio (ER) and the sharpness of the vessel wall were quantified. Two experienced radiologists evaluated the image quality on a 0-5 scale.Both 3 and 7 T achieved good image quality with high resolution (nominal 0.5 mm isotropic) and whole brain coverage. The CRwall-lumen and the ER measurements were comparable (p > 0.05). The 7 T images were significantly sharper (sharpness: 2.69 +/- 0.50 vs. 1.88 +/- 0.53 mm(-1), p < 0.001) with higher image quality (reader 1 score: 3.5 +/- 1.1 vs. 2.4 +/- 1.1, p = 0.002) compared to 3 T.3D T (1)-weighted SPACE can be used for intracranial vessel wall evaluation at both 3 and 7 T. 7 T provides significantly better image quality and improves the confidence of diagnosis.