MOLECULAR NEUROBIOLOGY OF DRUG-ADDICTION
MOLECULAR NEUROBIOLOGY OF DRUG-ADDICTION
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DOI：
10.1038/npp.1994.37
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发表时间：
1994-10-01
影响因子：
7.6
通讯作者：
NESTLER, EJ
中科院分区：
文献类型：
--
作者：
NESTLER, EJ
本综述的目的是阐明分子神经生物学研究如何有助于提高对毒瘾的理解，并最终开发更有效的治疗方法。需要对药物成瘾进行此类分子研究，以建立两种一般类型的信息：（1）病理生理学机制，识别滥用药物在大脑中产生的导致成瘾的变化； (2) 个人风险机制，识别增加或减少个人成瘾脆弱性的特定遗传和环境因素。这一信息有一天将带来治疗和预防成瘾性疾病的全新方法。
The purpose of this review is to illustrate the ways in which molecular neurobiological investigations will contribute to an improved understanding of drug addiction and, ultimately, to the development of more effective treatments. Such molecular studies of drug addiction are needed to establish two general types of information: (1) mechanisms of pathophysiology, identification of the changes that drugs of abuse produce in the brain that lead to addiction; and (2) mechanisms of individual risk, identification of specific genetic and environmental factors that increase or decrease an individual's vulnerability for addiction. This information will one day lead to fundamentally new approaches to the treatment and prevention of addictive disorders.