Clinical significance of circulating vascular cell adhesion molecule-1 to white matter disintegrity in Alzheimer's dementia
Clinical significance of circulating vascular cell adhesion molecule-1 to white matter disintegrity in Alzheimer's dementia
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DOI：
10.1160/th14-11-0938
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发表时间：
2015-12-01
影响因子：
6.7
通讯作者：
Chang, Chiung-Chih
中科院分区：
文献类型：
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作者：
Huang, Chi-Wei;Tsai, Meng-Han;Chang, Chiung-Chih
内皮功能障碍导致阿尔茨海默氏痴呆（AD）患者认知能力下降。虽然脑血管危险因素和内皮功能障碍都会导致血管细胞粘附分子-1 （VCAM-1）、细胞间粘附分子-1 （ICAM-1）和e-选择素的激活，但尚不清楚这些生物标志物是否能扩展反映脑内结构损伤或认知能力的诊断范围。共有110名AD患者和50名年龄匹配的对照组被纳入研究。测量血浆中VCAM-1、ICAM-1和e -选择素的水平，并将其与认知能力、白质宏观结构变化和主要神经束特异性分数各向异性量化相关。根据临床痴呆评分对AD患者进行分层（轻度痴呆，n=60；中重度痴呆，n= 50）。与对照组比较，血浆VCAM-1水平(p
Endothelial dysfunction leads to worse cognitive performance in Alzheimer's dementia (AD). While both cerebrovascular risk factors and endothelial dysfunction lead to activation of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and E-selectin, it is not known whether these biomarkers extend the diagnostic repertoire in reflecting intracerebral structural damage or cognitive performance. A total of 110 AD patients and 50 age-matched controls were enrolled. Plasma levels of VCAM-1, ICAM-1 and E-selectin were measured and correlated with the cognitive performance, white matter macro-structural changes, and major tract-specific fractional anisotropy quantification. The AD patients were further stratified by clinical dementia rating score (mild dementia, n=60; moderate-to-severe dementia, n= 50). Compared with the controls, plasma levels of VCAM-1 (p