Precision of High Definition Spectral-Domain Optical Coherence Tomography for Measuring Central Corneal Thickness
Precision of High Definition Spectral-Domain Optical Coherence Tomography for Measuring Central Corneal Thickness
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DOI：
10.1167/iovs.11-9033
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发表时间：
2012-04-01
影响因子：
4.4
通讯作者：
Maldonado, Miguel J.
中科院分区：
文献类型：
--
作者：
Correa-Perez, Maria E.;Lopez-Miguel, Alberto;Maldonado, Miguel J.
目的.本研究旨在评估Cirrus高清晰度光学相干断层扫描（HD-OCT）测量健康受试者中央角膜厚度（CCT）的可靠性及其与超声角膜厚度测量的准确性。招募了77名连续受试者，以评估重复性和两名检查员之间的一致性。为了分析重复性，一名检查者连续四次测量77只眼睛。为了研究两个观察者之间的一致性，第二个独立培训的检查者获得了另一个CCT测量值。我们还使用标准超声角膜厚度测量法测量了一个由20名患者组成的亚组的眼睛。获得了受试者内标准差（S-W）、变异系数（CV）、一致性限（LoA）和组内相关系数（ICC）数据。结果。对于重复性，S-W和精密度（1.96 x S-W）分别为4.86和9.52 μ m。观察者内CV为0.89%，ICC为0.98（95%置信区间[CI]，0.97-0.99）。对于两个检查员之间的协议，S-W和精密度分别为7.58和14.85 μ m，CV为1.40%。观察者之间的平均差异为-0.13 μ m（95%CI，-1.85至1.58; P = 0.87）。LoA的宽度为29.64 μ m。Cirrus HD-OCT和超声CCT测量值之间的中位差异为-4.5 μ m（四分位距，-7.0-0.0; P = 0.04）。Cirrus HD-OCT提供了可重复的CCT测量，两名独立培训的检查者之间具有良好的一致性，与超声角膜厚度测量相比，其系统偏倚在临床上可忽略不计。因此，使用Cirrus HD-OCT作为诊断成像方法的研究实验室和眼科诊所在为青光眼患者和接受角膜和屈光手术的患者提供咨询时，也可以从可靠的非接触式测厚仪中受益。（Invest Ophthalmol维斯科学。2012;53：1752-1757）DOI：10.1167/iovs.11-9033
PURPOSE. This study was intended to assess the reliability of central corneal thickness (CCT) measurements using Cirrus high-definition optical coherence tomography (HD-OCT) in healthy subjects and its accuracy compared with ultrasonic pachymetry.METHODS. Seventy-seven consecutive subjects were recruited for evaluating repeatability, and agreement between two examiners. To analyze repeatability, one examiner measured 77 eyes four times in succession. To study agreement between two observers, a second independently trained examiner obtained another CCT measurement. We also measured eyes in a subgroup of 20 patients using standard ultrasonic pachymetry. Within-subject standard deviation (S-W), coefficient of variation (CV), limits of agreement (LoA), and intraclass correlation coefficient (ICC) data were obtained.RESULTS. For repeatability, the S-W and precision (1.96 x S-W) were 4.86 and 9.52 mu m, respectively. Intraobserver CV was 0.89% and the ICC was 0.98 (95% confidence interval [CI], 0.97-0.99). For agreement between two examiners, the S-W and precision were 7.58 and 14.85 mu m, respectively; the CV was 1.40%. The mean difference between observers was -0.13 mu m (95% CI, -1.85 to 1.58; P = 0.87). The width of the LoA was 29.64 mu m. Median difference between Cirrus HD-OCT and ultrasound CCT measurements was -4.5 mu m (interquartile range, -7.0-0.0; P = 0.04).CONCLUSIONS. Cirrus HD-OCT provides repeatable CCT measurements, good agreement between two independently trained examiners, and its systematic bias compared to ultrasonic pachymetry is clinically negligible. Therefore, research laboratories and eye clinics using Cirrus HD-OCT as a diagnostic imaging method, can also benefit from a reliable noncontact pachymeter when counseling patients with glaucoma and those undergoing corneal and refractive surgeries. (Invest Ophthalmol Vis Sci. 2012;53:1752-1757) DOI:10.1167/iovs.11-9033