Pharmacokinetic study of minister, adjuvant, and guide herbs in Mahuang Decoction to ephedrine in monarch herb in vivo
Pharmacokinetic study of minister, adjuvant, and guide herbs in Mahuang Decoction to ephedrine in monarch herb in vivo
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发表时间：
2005
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通讯作者：
Luo Jia-bo
中科院分区：
文献类型：
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作者：
Luo Jia-bo
目的建立人血浆中麻黄碱的GC-MS测定方法，并研究麻黄汤中臣、佐、使药与君药不同配伍时麻黄碱的药代动力学参数。方法采用正交设计法确定麻黄汤的8个配伍组。将健康男性志愿者随机分为两组，每组8名。口服药物后，会在不同的时间抽取静脉血。测定血浆中麻黄碱浓度，绘制药时曲线，用WinNonlin 4.0.1软件计算各组药动学参数。药动学参数采用SPSS10.0软件进行统计学分析。结果所有药物浓度-时间曲线均符合一级吸收一室模型，无滞后时间。麻黄碱的部分参数在不同配伍组间差异显著（P0.05）。统计学结果显示，MHD中各中药间存在交互作用（P0.05）。结论MHD的臣、佐、使药对君药中麻黄碱的药代动力学参数有一定影响。
Objective To develop a GC-MS method for the determination of ephedrine in human plasma and study the pharmacokinetic parameters of the ephedrine in different compatibility of the minister, adjuvant, and guide herbs to the monarch herb in Mahuang Decoction. Methods Orthogonal design was used to determine eight compatible groups from Mahuang Decoction (MHD). The healthy male volunteers were divided into groups in random, each group concluding eight men. After taking the medicine orally, venous blood would be taken out at different times. Determining ephedrine in plasma and plotting the concentration-time curve, the pharmacokinetic parameters of each compatible group were calculated by WinNonlin 4.0.1. The statistical analysis of the pharmacokinetic parameters were proceeded by SPSS 10.0. Results All concentration-time curves were adequately modeled by one compartment, first order absorption model, and no lag time. Some parameters of ephedrine showed significant variance (P0.05) in different compatible groups. The statistic results showed interactions among herbs in MHD (P0.05). Conclusion The minister, adjuvant, and guide herbs of MHD have some certain effect on the pharmacokinetic parameters of ephedrine in the monarch herb.