Comparison of a very low-calorie-ketogenic diet with a standard low-calorie diet in the treatment of obesity
Comparison of a very low-calorie-ketogenic diet with a standard low-calorie diet in the treatment of obesity
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DOI：
10.1007/s12020-014-0192-3
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发表时间：
2014-12-01
期刊：
影响因子：
3.7
通讯作者：
Casanueva, Felipe F.
中科院分区：
文献类型：
--
作者：
Moreno, Basilio;Bellido, Diego;Casanueva, Felipe F.
在大多数工业化国家，肥胖症的全球流行率显著增加。抗肥胖药物稀缺，改变其生活方式的指征不切实际。因此，必须确定能够产生显著和持续体重减轻的饮食。本研究评价了极低热量生酮（VLCK）饮食对肥胖症的疗效。将一组肥胖患者随机分为两组：VLCK饮食组和标准低热量饮食（LC组）。随访12个月。两组均接受了外部支持、咨询、进行体育活动和坚持饮食。VLCK饲料诱导了30-45天的轻度酮症，并在15天内对体重产生了显著影响。在2个月时，VLCK饮食组和LC饮食组的体重分别减少了13.6 +/- A 3.9和4.8 +/- A 2.7 kg（p < 0.0001）。在研究结束时，即12个月时，体重分别减轻了19.9 ± A 12.3和7.0 ± A 5.6 kg（p < 0.0001），VLCK饮食组中超过88%的患者体重减轻了初始体重的10%以上。瘦体重几乎不受影响。VLCK饮食耐受良好，副作用为中度和一过性。在一组肥胖患者中，VLCK饮食明显比标准LC饮食更有效。在一年的随访中，VLCK饮食组的大多数患者体重减轻了初始体重的10%以上，瘦体重得到了很好的保持。
The global prevalence of obesity has significantly increased in most industrialized countries. Anti-obesity drugs are scarce, and indications to change their life style are impractical. Therefore, to identify diets able to produce significantly and maintained weight loss is mandatory. The present work evaluated the efficacy of a very low-calorie-ketogenic (VLCK) diet in obesity. A group of obese patients were randomized into two groups: the VLCK diet group and a standard low-calorie diet (LC group). The follow-up period was 12 months. Both groups received external support, counseling, to perform physical activity and adhered to the diet. The VLCK diet induced a 30-45 days of mild ketosis and significant effects on body weight within 15 days. At 2 months, the weight reductions in the VLCK diet and LC diet groups were 13.6 +/- A 3.9 and 4.8 +/- A 2.7 kg, respectively (p < 0.0001). At the end of the study, at 12 months, the weight reductions were 19.9 +/- A 12.3 and 7.0 +/- A 5.6 kg, respectively (p < 0.0001), and more than 88 % of patients in the VLCK diet group lost more of 10 % of their initial weight. Lean mass was practically unaffected. The VLCK diet was well tolerated and the side effects were moderate and transitory. In a group of obese patients, the VLCK diet was significantly more effective than a standard LC diet. At one year follow-up in the group with VLCK diet, most of the patients loss more than 10 % of their initial weight and lean mass was well preserved.