Patterns of chromosomal duplication in maize and their implications for comparative maps of the grasses
Patterns of chromosomal duplication in maize and their implications for comparative maps of the grasses
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DOI：
10.1101/gr.160601
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发表时间：
2001-01-01
期刊：
影响因子：
7
通讯作者：
Gaut, BS
中科院分区：
文献类型：
--
作者：
Gaut, BS
玉米基因组包含大量的染色体复制，可能是由一个古老的四倍体事件产生的。比较谷物图谱已经确定了玉米中至少10个重复或同源的染色体区域。然而，用于从比较图谱中记录染色体同源性的方法并不是统计的，它们的标准往往不明确。本文描述了一种检验染色体间标记共线性统计意义的模拟方法的发展，以及该方法在玉米分子图谱上的应用。该方法记录了24对玉米染色体之间的共线性，表明玉米的同源性比比较谷物图谱所代表的要复杂得多。结果还显示，60%-82%的基因组被保留在共线区域，多达三分之一的基因组可能存在于多个副本中。总而言之，玉米染色体之间的复杂共线性模式表明，目前的比较谷物图谱不能充分代表玉米基因组的进化和组织。
The maize genome contains extensive chromosomal duplications that probably were produced by an ancient tetraploid event. Comparative cereal maps have identified at least 10 duplicated, or homologous chromosomal regions within maize. However, the methods used to document chromosomal homologies from comparative maps are not statistical, and their criteria are often unclear. This paper describes the development of a simulation method to test For the statistical significance of marker colinearity between chromosomes, and the application of the method to a molecular map of maize. The method documents colinearity among 24 pairs of maize chromosomes, suggesting homology in maize is more complex than represented by comparative cereal maps. The results also reveal that 60%-82% of the genome has been retained in colinear regions and that as much as a third of the genome could be present in multiple copies. Altogether, the complex pattern of colinearity among maize chromosomes suggests that current comparative cereal maps do not adequately represent the evolution and organization of the maize genome.