A cell type-specific cortico-subcortical brain circuit for investigatory and novelty-seeking behavior
A cell type-specific cortico-subcortical brain circuit for investigatory and novelty-seeking behavior
复制标题
DOI：
10.1126/science.abe9681
复制
发表时间：
2021-05-14
期刊：
影响因子：
56.9
通讯作者：
Heimel, J. Alexander
中科院分区：
文献类型：
--
作者：
Ahmadlou, Mehran;Houba, Janou H. W.;Heimel, J. Alexander
探索自然环境和社会环境对于理解周围世界至关重要。我们不知道追求新奇的动机是如何启动构成调查行为的复杂行动序列的。我们在小鼠中发现，丘脑下脑区内侧无动带（ZIm）中的抑制性神经元对于决定调查物体或同物是必不可少的。这些神经元接受来自前边缘皮层的兴奋性输入，发出探索开始的信号。这个信号在ZIm中被调查动机的水平调制。ZIm的活动增加通过抑制导水管周围灰色区来激发深度调查行动。抑制性ZIm神经元亚群表达速激肽1 （TAC1）调节调查行为。
Exploring the physical and social environment is essential for understanding the surrounding world. We do not know how novelty-seeking motivation initiates the complex sequence of actions that make up investigatory behavior. We found in mice that inhibitory neurons in the medial zona incerta (ZIm), a subthalamic brain region, are essential for the decision to investigate an object or a conspecific. These neurons receive excitatory input from the prelimbic cortex to signal the initiation of exploration. This signal is modulated in the ZIm by the level of investigatory motivation. Increased activity in the ZIm instigates deep investigative action by inhibiting the periaqueductal gray region. A subpopulation of inhibitory ZIm neurons expressing tachykinin 1 (TAC1) modulates the investigatory behavior.