Stable and Well-Organized Near-Infrared Platinum(II)-Acetylide-Based Metallacycles-Mediated Cancer Phototherapy
Stable and Well-Organized Near-Infrared Platinum(II)-Acetylide-Based Metallacycles-Mediated Cancer Phototherapy
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DOI：
10.1021/acsami.0c01695
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发表时间：
2020-05-06
影响因子：
9.5
通讯作者：
Zhao, Qiang
中科院分区：
文献类型：
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作者：
Li, Guo;Zhang, Xiangxiang;Zhao, Qiang
开发具有高稳定性和强近红外（NIR）吸收的金属杂环化合物对于生物医学应用具有重要意义。然而，很少有分子设计策略已经开发了这样的金属杂环。在此，我们报告了一系列新的稳定和定义明确的近红外吸收金属杂环（M1-M3）通过Pt-乙炔配位具有高效的光转换性能的癌症光疗。金属杂环化合物表现出很高的稳定性和很强的近红外吸收，与相应的前体相比，其吸收峰红移了约30 nm。金属配合物中引入Pt促进了显着的光转换，包括单线态到三线态和非辐射跃迁。此外，所制备的M3纳米颗粒（M3-NPs）在NIR照射下表现出良好的光转化为热效应和单线态氧生成，实现肿瘤消融。这种新颖的Pt-乙炔基金属杂环化合物不仅具有复杂的拓扑结构，而且为精确的癌症光疗提供了一个有价值的范例，这对于在金属杂环化合物上接枝刺激响应性功能基团以开发高性能生物医用超分子材料具有重要意义。
The development of metallacycles with high stability and intense near-infrared (NIR) absorption is important for biomedical applications. However, very few molecular design strategies have been developed on such metallacycles. Herein, we report a new series of stable and well-defined NIR-absorbing metallacycles (M1-M3) through the Pt-acetylide coordination with highly efficient photoconversion performance for cancer phototherapy. The metallacycles showed high stability and strong NIR absorption, and the absorption peaks were red shifted approximately 30 nm in comparison with their corresponding precursors. The introduction of Pt into metallacycles promotes significant photoconversions, including the singlet-to-triplet and nonradiative transitions. Moreover, the fabricated M3 nanoparticles (M3-NPs) showed favorable photoconversions into both thermal effect and singlet oxygen generation upon NIR irradiation, achieving tumor ablation. This novel design of Pt-acetylide metallacycles possesses not only complex topological architectures but also a valuable paradigm for precise cancer phototherapy, which is important for grafting stimuli-responsive functional groups into metallacycles for the development of high-performance biomedical supramolecular materials.