Brain Tissue Pulsatility is Increased in Midlife Depression: a Comparative Study Using Ultrasound Tissue Pulsatility Imaging
Brain Tissue Pulsatility is Increased in Midlife Depression: a Comparative Study Using Ultrasound Tissue Pulsatility Imaging
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DOI：
10.1038/npp.2017.113
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发表时间：
2017-12-01
影响因子：
7.6
通讯作者：
Camus, Vincent
中科院分区：
文献类型：
--
作者：
Desmidt, Thomas;Brizard, Bruno;Camus, Vincent
脑血管疾病（CVD）一直与晚年抑郁症有关，但在中年抑郁症中的记录很少。可以假设，传统的神经影像学技术的敏感性相对较低，不允许在中年抑郁症中检测到微妙的CVD。我们使用组织脉动成像（TPI），一种新的超声（US）神经成像技术，已被证明具有良好的灵敏度，以检测小脑体积的脉动变化，以识别中年抑郁症的脑血管功能的早期和微妙的变化。我们比较了三组年龄匹配的中年女性之间的最大和平均脑组织脉动性（MaxBTP和MeanBTP）：抑郁症患者（n = 25），缓解抑郁症患者（n = 24）和社区对照组（n = 25）。MRI动脉自旋标记、白色高信号（WMH）和经颅多普勒（TCD）被用作CVD的对照常规标记物。我们发现三组之间的MRI和TCD测量值无差异。与此相反，抑郁症患者表现出增加的BTP相关的平均全球脑脉动（MeanBTP）和没有变化相关的大血管（MaxBTP）与缓解组和对照组相比。超声神经成像是一种检测与脑血管功能相关的脑脉动性变化的高度准确方法，TPI发现中年抑郁患者的BTP增加，表明该CVD风险人群（如卒中或WMH）存在早期和轻微的血管损伤。由于高脉动性可能代表前驱脑血管变化，随着时间的推移会损害大脑，因此本文提供了一个潜在的靶点来阻断CVD的进展。
Cerebrovascular disease (CVD) is consistently associated with late-life depression but poorly documented in midlife depression. It can be hypothesized that the relatively low sensitivity of conventional neuroimaging techniques does not allow the detection of subtle CVD in midlife depression. We used tissue pulsatility imaging (TPI), a novel ultrasound (US) neuroimaging technique that has demonstrated good sensitivity to detect changes in the pulsatility of small brain volumes, to identify early and subtle changes in brain vascular function in midlife depression. We compared the maximum and mean brain tissue pulsatility (MaxBTP and MeanBTP), as identified by TPI, between three groups of middle-aged females matched for age: patients with depression (n = 25), patients with remitted depression (n = 24) and community controls (n = 25). MRI arterial spin labeling, white matter hyperintensities (WMHs) and transcranial doppler (TCD) were used as control conventional markers for CVD. We found no difference in the MRI and TCD measures among the three groups. In contrast, depressive patients showed an increased BTP related to the mean global brain pulsatility (MeanBTP) and no change related to large vessels (MaxBTP) in comparison with the remitted and control groups. US neuroimaging is a highly accurate method to detect brain pulsatility changes related to cerebrovascular functioning, and TPI identified an increased BTP in midlife depressed patients, suggesting early and subtle vascular impairments in this population at risk for CVD such as stroke or WMHs. Because high pulsatility could represent prodromal cerebrovascular changes that damage the brain over time, this paper provides a potential target for blocking the progression of CVD.