Gut bacteria affect the tumoral immune milieu: distorting the efficacy of immunotherapy or not?
Gut bacteria affect the tumoral immune milieu: distorting the efficacy of immunotherapy or not?
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肠道细菌影响肿瘤免疫环境：是否会扭曲免疫疗法的疗效？
DOI：
10.1080/19490976.2020.1739794
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发表时间：
2020
期刊：
影响因子：
12.2
通讯作者：
Chang Pengyu
中科院分区：
文献类型：
--
作者：
Pu Xiaoyu;Ge Chao;Dong Lihua;Chang Pengyu
使用免疫检查点抑制剂的免疫疗法正在给肿瘤疗法带来革命性的变化。然而，由于部分癌症患者缺乏适当的生物标志物，免疫治疗的应用可能会受到限制。最近，新出现的证据表明，肠道共生细菌可以影响免疫检查点抑制剂在几种癌症模型中的治疗效果。此外，肠道细菌组成的检测为预测免疫疗法的疗效和毒性提供了背景。在这篇综述中，我们讨论了肠道共生细菌对肿瘤免疫环境的影响，重点介绍了一些典型的细菌及其与免疫治疗的关系。
Immunotherapy using immune-checkpoint inhibitors is revolutionizing oncotherapy. However, the application of immunotherapy may be restricted because of the lack of proper biomarkers in a portion of cancer patients. Recently, emerging evidence has revealed that gut commensal bacteria can impact the therapeutic efficacy of immune-checkpoint inhibitors in several cancer models. In addition, testing the composition of gut bacteria provides context for prediction of the efficacy and toxicity of immunotherapy. In this review, we discuss the impacts of gut commensal bacteria on the tumoral immune milieu, highlighting some typical bacteria and their associations with immunotherapy.