Dual stimuli-responsive fungicide carrier based on hollow mesoporous silica/hydroxypropyl cellulose hybrid nanoparticles
Dual stimuli-responsive fungicide carrier based on hollow mesoporous silica/hydroxypropyl cellulose hybrid nanoparticles
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DOI：
10.1016/j.jhazmat.2021.125513
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发表时间：
2021-03-10
影响因子：
13.6
通讯作者：
He, Shun
中科院分区：
文献类型：
--
作者：
Gao, Yunhao;Liu, Yu;He, Shun
基于纳米颗粒平台的农药控释技术由于其尺寸依赖性和靶标修饰性而成为提高农药效率和减少环境污染的新技术。在本研究中，pH/纤维素酶双重刺激响应控制释放制剂（PYR-HMS-HPC）通过接枝羟丙基纤维素吡唑醚菌酯负载中空介孔二氧化硅纳米粒通过酯键。采用傅里叶变换红外光谱、热重分析仪、透射电镜和扫描电镜对PYR-HMS-HPC配方进行了表征。结果表明，负载量为12.1wt%的PYR-HMS-HPC在酸性环境中表现出良好的吡唑醚菌酯释放性能，纤维素酶的引入能有效抑制吡唑醚菌酯的光解。与吡唑醚菌酯商品制剂相比，PYR-HMS-HPC制剂在7 - 21天内对稻瘟病菌表现出更强的杀菌活性，并且具有统计学显著性。此外，洋葱染色体畸变试验证明PYR-HMS-HPC制剂降低了吡唑醚菌酯的遗传毒性。这些pH/纤维素酶双重刺激响应控释制剂对于可持续的按需作物病害保护具有极大的意义。
The controlled release of pesticides based on nanoparticle platforms has emerged as a new technology for increasing the efficiency of pesticides and for reducing environmental pollution because of their size-dependent and target-modifying properties. In the present study, pH/cellulase dual stimuli-responsive controlled-release formulations (PYR-HMS-HPC) were designed by grafting hydroxypropyl cellulose onto pyraclostrobin-loaded hollow mesoporous silica nanoparticles via an ester linkage. The PYR-HMS-HPC formulations were characterized by Fourier transform infrared spectroscopy, thermogravimetric analyzer, transmission electron microscope and scanning electron microscope. The results demonstrated that PYR-HMS-HPC with a loading capacity of 12.1 wt% showed excellent pyraclostrobin release behaviors in response to acidic environments and the introduction of cellulase, could effectively prevented pyraclostrobin from photolysis. Compared with commercial pyraclostrobin formulations, the PYR-HMS-HPC formulations showed much stronger and statistically significant fungicidal activity against Magnaporthe oryzae from 7 to 21 days. Furthermore, the Allium cepa chromosome aberration assay demonstrated that the PYR-HMS-HPC formulations reduced the genotoxicity of pyraclostrobin. These pH/ cellulase dual stimuli-responsive controlled-release formulations are of great interest for sustainable on-demand crop disease protection.