Distinct expression of SARS‐CoV‐2 receptor ACE2 correlates with endotypes of chronic rhinosinusitis with nasal polyps
Distinct expression of SARS‐CoV‐2 receptor ACE2 correlates with endotypes of chronic rhinosinusitis with nasal polyps
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DOI：
10.1111/all.14665
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发表时间：
2020-11
期刊：
影响因子：
12.4
通讯作者：
Ming Wang;Xiangting Bu;G. Fang;Ge Luan;Yanran Huang;C. Akdis;Chengshuo Wang;Luo Zhang
中科院分区：
文献类型：
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作者：
Ming Wang;Xiangting Bu;G. Fang;Ge Luan;Yanran Huang;C. Akdis;Chengshuo Wang;Luo Zhang
严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）进入因子ACE 2和TMPRSS 2在鼻上皮细胞中高度表达。然而，尚未研究SARS-CoV-2与慢性鼻窦炎伴鼻息肉（CRSwNP）的鼻腔炎症之间的关系。因此，我们研究了CRSwNP患者鼻组织中SARS-CoV-2进入因子的表达，以及它们与CRSwNP炎性内型的相关性。
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) entry factors, ACE2 and TMPRSS2, are highly expressed in nasal epithelial cells. However, the association between SARS‐CoV‐2 and nasal inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP) has not been investigated. We thus investigated the expression of SARS‐CoV‐2 entry factors in nasal tissues of CRSwNP patients, and their associations with inflammatory endotypes of CRSwNP.