Two kinds of items in quality of life instruments: 'Indicator and causal variables' in the EORTC QLQ-C30
Two kinds of items in quality of life instruments: 'Indicator and causal variables' in the EORTC QLQ-C30
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DOI：
10.1007/s11136-005-8290-6
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发表时间：
2006-02-01
影响因子：
3.5
通讯作者：
Luszczynska, A
中科院分区：
文献类型：
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作者：
Boehmer, S;Luszczynska, A
在测量健康相关生活质量(HRQOL)的工具中，可以区分两种变量。身体症状可以被称为因果变量，因为它们的出现会导致HRQOL的变化，但HRQOL差并不一定意味着患者患有这些症状。其他项目可视为指标变量。它们反映了HRQOL的水平，HRQOL较差的患者在所有指标变量上的得分可能都很低。本研究的目的是检验潜在的HRQOL结构与EORTC QLQ-C30上的条目和领域的关系。对205例胃肠道肿瘤患者术后1个月的EORTC QLQ-C30数据进行验证性因素分析。功能量表被建立为指示HRQOL水平的变量，而所有其他子量表和条目被建立为导致HRQOL变化的变量。模型数据拟合效果令人满意。结果支持这一假设，即在HRQOL量表中可以区分两种变量。进一步的研究应该调查这两种变量是否可以组合成更高的顺序，即HRQOL的总分。
Two kinds of variables may be differentiated within instruments measuring health-related quality of life (HRQOL). Physical symptoms may be called causal variables because their occurrence can cause a change in HRQOL, but poor HRQOL need not necessarily imply that a patient suffers from these symptoms. Other items can be regarded as indicator variables. They reflect the level of HRQOL and a patient with a poor HRQOL is likely to have low scores on all indicator variables. The aim of this study was to test the relationship of the latent HRQOL construct to items and domains on the EORTC QLQ-C30. Confirmatory factor analysis was performed on EORTC QLQ-C30 data from 205 gastrointestinal cancer patients assessed one month after surgery. Functioning scales were established as variables indicating the level of HRQOL whereas all other subscales and items were established as variables causing a change in HRQOL. The model-data fit was satisfactory. Results support the hypothesis that two kinds of variables may be differentiated within HRQOL instruments. Further research should investigate whether both kinds of variables could be combined into a higher order, aggregate score for HRQOL.