Extragonadal germ cell tumor of the prostate associated with Klinefelter's syndrome
Extragonadal germ cell tumor of the prostate associated with Klinefelter's syndrome
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DOI：
10.1046/j.1442-2042.1999.06314.x
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发表时间：
1999-03-01
影响因子：
2.6
通讯作者：
Furusato, M
中科院分区：
文献类型：
--
作者：
Namiki, K;Tsuchiya, A;Furusato, M
摘要目的：我们报告一个合并克氏症候群的摄护腺外生殖细胞肿瘤病例。方法/结果：患者为33岁男性，经直肠前列腺穿刺活检提示合并生殖细胞肿瘤（卵黄囊瘤+畸胎瘤）。因为除了前列腺外没有肿瘤，我们认为这是一个原发性前列腺性腺外生殖细胞肿瘤。前列腺肿瘤对顺铂、长春碱和博莱霉素的全身化疗有反应，乳酸脱氢酶和甲胎蛋白水平升高恢复正常。除化疗外，患者还接受了放射治疗。结论：患者自诊断以来已存活约4年。
Purpose: We report on a case of extragonadal germ cell tumor of the prostate associated with Klinefelter's syndrome. Methods/Results: The patient was a 33-year-old man. A transrectal prostate biopsy suggested combined germ cell tumor (yolk sac tumor + teratoma). Because there was no tumor except from the prostate, we considered this case to be a primary extragonadal germ cell tumor of the prostate. The prostate tumor responded to systemic chemotherapy with cisplatin, vinblastine and bleomycin and elevated lactate dehydrogenase and alpha-fetoprotein levels normalized. In addition to chemotherapy, the patient also underwent radiation therapy. Conclusion: The patient has survived for approximately 4 years since the diagnosis.