CARDIOTONIC ACTIVITY OF 2,5-DIMETHOXYPHENYLIMIDAZO[2,1-B]-THIAZOLES
CARDIOTONIC ACTIVITY OF 2,5-DIMETHOXYPHENYLIMIDAZO[2,1-B]-THIAZOLES
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DOI：
10.1002/ardp.19853181109
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发表时间：
1985-01-01
影响因子：
5.1
通讯作者：
GALATULAS, I
中科院分区：
文献类型：
--
作者：
ANDREANI, A;RAMBALDI, M;GALATULAS, I
报道了咪唑类[2,1-b]噻唑类和6位2,5-二甲氧基苯基-噻唑类化合物的合成及其活性。在离体豚鼠心房中研究了其肌力活性。化合物10表现出强烈的正性肌力活性：它增加正常和低动力心肌的心肌收缩力。
We report about the synthesis and the activities of imidazo[2,1-b]thiazoles and -thiazolines bearing a 2,5-dimethoxyphenylgroup at position 6. The inotropic activity was investigated in isolated guinea pig atria. Compound 10 shows a strong positive inotropic activity: it increases the myocardial contractility in normal and hypodynamic heart muscle.