OLIGOSACCHARIDE LIGANDS FOR NKR-P1 PROTEIN ACTIVATE NK CELLS AND CYTOTOXICITY (Retracted article. See vol. 500, pg. 492, 2013)
OLIGOSACCHARIDE LIGANDS FOR NKR-P1 PROTEIN ACTIVATE NK CELLS AND CYTOTOXICITY (Retracted article. See vol. 500, pg. 492, 2013)
复制标题
DOI：
10.1038/372150a0
复制
发表时间：
1994-11-10
期刊：
影响因子：
64.8
通讯作者：
FEIZI, T
中科院分区：
文献类型：
--
作者：
BEZOUSKA, K;YUEN, CT;FEIZI, T
A diversity of high-affinity oligosaccharide ligands are Identified for NKR-P1, a membrane protein on natural killer (NH) cells which contains an extracellular Ca2+-dependent lectin domain. Interactions of such oligosaccharides on the target cell surface with NKR-P1 on the killer cell surface are crucial both for target cell recognition and for delivery of stimulatory or inhibitory signals linked to the NH cytolytic machinery. NK-resistant tumour cells are rendered susceptible by preincubation with liposomes expressing NKR-P1 ligands, suggesting that purging of tumour or virally infected cells in vivo may be a therapeutic possibility.
