THE USE OF NIFEDIPINE DURING THE POSTPARTUM PERIOD IN PATIENTS WITH SEVERE PREECLAMPSIA
THE USE OF NIFEDIPINE DURING THE POSTPARTUM PERIOD IN PATIENTS WITH SEVERE PREECLAMPSIA
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DOI：
10.1016/0002-9378(90)91011-z
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发表时间：
1990-03-01
影响因子：
9.8
通讯作者：
CONOVER, WB
中科院分区：
文献类型：
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作者：
BARTON, JR;HIETT, AK;CONOVER, WB
硝苯地平是一种钙通道阻滞剂，可降低血压，增加肾血流量。本双盲研究评价硝苯地平对产后重度子痫前期患者的疗效。31例患者随机接受硝苯地平（10毫克）或安慰剂，每4小时开始后立即交付。数据分析显示，硝苯地平组在分娩后24小时内的尿量显著较高（3834对2057 ml; p < 0.05）。硝苯地平组在产后18 - 24小时平均动脉压也显著降低（93.9对100.2 mm Hg; p < 0.05）。在收缩压或舒张压、脉搏、实验室研究结果或是否需要给予肼苯哒嗪控制血压方面没有显著差异。硝苯地平似乎对重度子痫前期患者产后24小时内的尿量和平均动脉压有有益作用。
Nifedipine is a calcium channel blocker that reduces blood pressure and increases renal blood flow. This double-blind investigation evaluated the effect of nifedipine in postpartum patients with severe preeclampsia. Thirty-one patients were randomized to receive either nifedipine (10 mg) or placebo every 4 hours beginning immediately after delivery. Data analysis revealed a significantly higher urine output in the nifedipine group during the first 24 hours after delivery (3834 versus 2057 ml; p < 0.05). A significant reduction in mean arterial pressure was also noted in the nifedipine group between 18 and 24 hours postpartum (93.9 versus 100.2 mm Hg; p < 0.05). There were no significant differences in the systolic or diastolic blood pressures, pulse, laboratory study results, or the need to administer hydralazine to control blood pressure. Nifedipine appears to have a beneficial effect on urinary output and mean arterial pressure during the first 24 hours post partum in patients with severe preeclampsia.