Depression, anxiety, health-related quality of life and pain in patients with chronic. bromyalgia and neuropathic pain
Depression, anxiety, health-related quality of life and pain in patients with chronic. bromyalgia and neuropathic pain
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DOI：
10.1016/j.ejpain.2009.03.010
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发表时间：
2010-02-01
影响因子：
3.6
通讯作者：
Jensen, Troels S.
中科院分区：
文献类型：
--
作者：
Gormsen, Lise;Rosenberg, Raben;Jensen, Troels S.
慢性疼痛通常与焦虑和抑郁等合并症有关，导致健康相关的生活质量低下。这种关联的机制尚不清楚，但已经提出了脑干疼痛控制系统的干扰。神经性疼痛（NP）患者30例，神经性疼痛（NP）患者28例。26名无疼痛的年龄和性别匹配的对照者被纳入并检查精神困扰（自评症状检查表-92）、抑郁（医生评定的汉密尔顿抑郁量表和自评严重抑郁量表）和焦虑（医生评定的汉密尔顿焦虑量表和自评焦虑量表）。此外，患者还评估了其健康相关生活质量（SF-36）。慢性疼痛患者FM和NP有显着更多的精神困扰，包括抑郁和焦虑比健康对照组的自我评价和专业评级。然而，与其他关于慢性疼痛患者精神困扰的研究相比，这些评分较低。只有少数慢性疼痛患者符合抑郁症的诊断标准（NP 3.3%，FM 7.1%），尽管疼痛强度相似，但疼痛和精神症状之间的关联仅在FM组中发现。研究结果表明，不同的机制是负责发展的情绪障碍，在两个病人群体。(C)2009年，国际疼痛分会研究协会欧洲联合会。由爱思唯尔有限公司出版。保留所有权利。
Chronic pain is often associated with comorbidities such as anxiety and depression, resulting in a low health-related quality of life. The mechanisms underlying this association are not clear, but a disturbance in the pain control systems from the brain stem has been suggested. Thirty neuropathic pain (NP) patients, 28 patients with. bromyalgia (FM), and 26 pain-free age-and gender-matched controls were included and examined with respect to mental distress (self-rated Symptom Checklist-92), depression (doctor-rated Hamilton Depression Scale and self-rated Major Depression Inventory), and anxiety (doctor-rated Hamilton Anxiety Scale and self-rated Anxiety Inventory). In addition, patients assessed their health-related quality of life (SF-36). Chronic pain patients with FM and NP had significantly more mental distress including depression and anxiety than healthy controls both by self-rating and by a professional rating. However, these scores are low compared to other studies on mental distress in chronic pain patients. Only few chronic pain patients meet the diagnostic criteria for depression (NP 3.3%, FM 7.1%), and associations between pain and mental symptoms were only found in the FM group despite similar pain intensities. The findings suggest that different mechanisms are responsible for the development of mood disorders in the two patient groups. (C) 2009 European Federation of International Association for the Study of Pain Chapters. Published by Elsevier Ltd. All rights reserved.