Relationship of Allergy with Asthma: There Are More Than the Allergy "Eggs" in the Asthma "Basket".
Relationship of Allergy with Asthma: There Are More Than the Allergy "Eggs" in the Asthma "Basket".
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DOI：
10.3389/fped.2017.00092
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发表时间：
2017
影响因子：
2.6
通讯作者：
Tsabouri S
中科院分区：
文献类型：
--
作者：
Guibas GV;Mathioudakis AG;Tsoumani M;Tsabouri S
哮喘和过敏有相似且非常接近的过程，尤其是在童年时期。为了理清这些关联，人们投入了大量的研究工作。然而，现在越来越明显的是，这是一项极其艰巨的任务。事实上，每一项研究突破都进一步使这一情况变得更加扑朔迷离，因为我们正在稳步迈向个性化医疗时代，我们开始认识到，我们认为是单一疾病的哮喘实际上是不同实体的积累。在这种“综合征”的背景下，其特征是几种尚未明确定义的内型和表型，“哮喘”与过敏之间的联系问题可能变得无关紧要。在这篇综述中，我们将重新审视这个问题，同时强调哮喘的多方面性质。
Asthma and allergy share a similar and very close course, especially through childhood. Considerable research effort has been put in untangling these associations; however, it is now becoming obvious that this is an exceedingly difficult task. In fact, each research breakthrough further perplexes this picture, as we are steadily moving toward the era of personalized medicine and we begin to appreciate that what we thought to be a single disease, asthma, is in fact an accumulation of distinct entities. In the context of this “syndrome,” which is characterized by several, as of yet poorly defined endotypes and phenotypes, the question of the link of “asthma” with allergy probably becomes non-relevant. In this review, we will revisit this question while putting the emphasis on the multifaceted nature of asthma.