EFFECT OF PHYSICAL EXERCISE ON SENSITIVITY AND RESPONSIVENESS TO INSULIN IN HUMANS
EFFECT OF PHYSICAL EXERCISE ON SENSITIVITY AND RESPONSIVENESS TO INSULIN IN HUMANS
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DOI：
10.1152/ajpendo.1988.254.3.e248
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发表时间：
1988-03-01
影响因子：
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通讯作者：
GALBO, H
中科院分区：
文献类型：
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作者：
MIKINES, KJ;SONNE, B;GALBO, H
研究了急性体育锻炼对胰岛素敏感性、葡萄糖摄取反应性和肝糖生成的影响。7名未经训练的男性在休息后(R)、运动后(E)以及150w测力器运动（ER） 60分钟后48小时接受了4次连续的正糖高胰岛素钳夹。胰岛素介导的葡萄糖摄取在E和ER天高于R天。运动后表观Km值降低（52 .+-）。3 . R对43 .+-。4 E和40 +-。3 . ER .mu。U/ml，表示+-。SE)和Vmax增加（9.5 +-）。0.8比10.9。0.7 E和10.7。0.8 ER毫克。最低为1 .cntdot。公斤)。葡萄糖氧化随胰岛素输注速率的增加而增加，最大葡萄糖氧化速率在第E天低于第R天。葡萄糖到糖原的最大转化率在E和ER天较高（8.0 .+-）。0.3和7.2 .+-。分别为0.2)，比R天(5.7 .+-。0.6 mg .cntdot。最低为1 .cntdot。公斤)。肌糖原合成酶I的活性在运动后立即升高，并在接下来的48小时内保持较高水平。没有任何血糖调节激素或代谢物的变化可以解释运动后胰岛素作用的增加。在另外的实验中（n = 3），运动后5天没有剩余效果。胰岛素和运动均抑制胰腺分泌胰岛素和胰岛素原。得出的结论是，长时间的适度运动通过降低表观Km和增加Vmax来增加胰岛素对人体葡萄糖摄取的作用。这种效果持续48小时，而不是5天。胰岛素作用的增加可能与运动引起的糖原合成酶活性的增加有关。
The effect of acute physical exercise on insulin sensitivity and responsiveness of glucose uptake and hepatic glucose production was studied. Seven untrained men were subjected to four sequential euglycemic hyperinsulinemic clamps after rest (R), immediately after exercise (E), as well as 48 h after 60 min of 150 W ergometer exercise (ER). Insulin-mediated glucose uptake was higher on E and ER days compared with R days. Apparent Km decreased after exercise (52 .+-. 3 R vs. 43 .+-. 4 E and 40 .+-. 3 ER .mu.U/ml, means .+-. SE) and Vmax increased (9.5 .+-. 0.8 R vs. 10.9 .+-. 0.7 E and 10.7 .+-. 0.8 ER mg .cntdot. min-1 .cntdot. kg-1). Glucose oxidation increased with the increasing insulin infusion rate, and maximal glucose oxidation rate was lower on E days compared with R days. The maximal conversion rate of glucose to glycogen was higher on E and ER days (8.0 .+-. 0.3 and 7.2 .+-. 0.2, respectively) than on R days (5.7 .+-. 0.6 mg .cntdot. min-1 .cntdot. kg-1). Muscle glycogen synthase I activity was higher immediately after exercise and remained higher for the next 48 h. No change in any glucoregulatory hormone or metabolite could explain the increased insulin action seen after exercise. In additional experiments (n = 3), no remaining effect existed 5 days after exercise. Both insulin and exercise suppressed the pancreatic secretion of insulin and proinsulin. The conclusions drawn are that prolonged moderate exercise increases insulin action on glucose uptake in humans by reducing apparent Km and increasing Vmax. This effect lasts 48 h but not 5 days. The increased insulin action may be related to an exercise-induced increase in glycogen synthase activity.