Does diffusion kurtosis imaging lead to better neural tissue characterization? A rodent brain maturation study
Does diffusion kurtosis imaging lead to better neural tissue characterization? A rodent brain maturation study
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DOI：
10.1016/j.neuroimage.2008.12.018
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发表时间：
2009-04-01
期刊：
影响因子：
5.7
通讯作者：
Wu, Ed X.
中科院分区：
文献类型：
--
作者：
Cheung, Matthew M.;Hui, Edward S.;Wu, Ed X.
扩散峰度成像（Diffusion kurtosis imaging， DKI）可以用来估计过量峰度，过量峰度是水扩散过程偏差的一种无因次度量。来自高斯分布。最近的一些研究应用DKI来探测生物组织中受限制的水扩散。此外，还发展了定向分析来获得定向特定峰度。然而，这些研究不能直接评价DKI在检测细微神经组织改变方面的敏感性。众所周知，脑成熟涉及各种影响水扩散特性的生物事件，因此为评估DKI的功效提供了一个敏感的平台。本研究采用3个不同年龄的正常Sprague-Dawley大鼠进行体内DKI实验，分别为出生后13、31和120天（每组N=6）。然后对4个白质（WM）和3个灰质（GM）结构进行区域分析。从DKI得到的扩散率和峰度估计对这些选择的结构的发育变化高度敏感。传统的弥散张量成像（DTI）参数也使用单指数模型计算，在监测脑成熟变化方面的灵敏度和定向特异性降低。这些结果表明，通过测量定向特异性扩散系数和峰度，DKI可以更全面、更灵敏地检测组织微结构变化。这种成像技术的进步可以更好地表征正常、发育和病理状态下的神经组织，无论是WM还是GM。(c) 2008爱思唯尔公司版权所有。
Diffusion kurtosis imaging (DKI) can be used to estimate excess kurtosis, which is a dimensionless measure for the deviation of water diffusion pro. le from Gaussian distribution. Several recent studies have applied DKI to probe the restricted water diffusion in biological tissues. The directional analysis has also been developed to obtain the directionally specific kurtosis. However, these studies could not directly evaluate the sensitivity of DKI in detecting subtle neural tissue alterations. Brain maturation is known to involve various biological events that can affect water diffusion properties, thus providing a sensitive platform to evaluate the efficacy of DKI. In this study, in vivo DKI experiments were performed in normal Sprague-Dawley rats of 3 different ages: postnatal days 13, 31 and 120 (N=6 for each group). Regional analysis was then performed for 4 white matter (WM) and 3 gray matter (GM) structures. Diffusivity and kurtosis estimates derived from DKI were shown to be highly sensitive to the developmental changes in these chosen structures. Conventional diffusion tensor imaging (DTI) parameters were also computed using monoexponential model, yielding reduced sensitivity and directional specificity in monitoring the brain maturation changes. These results demonstrated that, by measuring directionally specific diffusivity and kurtosis, DKI offers a more comprehensive and sensitive detection of tissue microstructural changes. Such imaging advance can provide a better MR diffusion characterization of neural tissues, both WM and GM, in normal, developmental and pathological states. (c) 2008 Elsevier Inc. All rights reserved.