Antibodies are forever: a study using 12-26-year-old expired antibodies
Antibodies are forever: a study using 12-26-year-old expired antibodies
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DOI：
10.1111/his.12225
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发表时间：
2013-12-01
期刊：
影响因子：
6.4
通讯作者：
Cattoretti, Giorgio
中科院分区：
文献类型：
--
作者：
Argentieri, Maria C.;Pilla, Daniela;Cattoretti, Giorgio
目的本研究的目的是调查诊断抗体的保质期是否长于标签上的有效期。方法和结果四个独立的实验室测试了少量的诊断抗体在+4 ℃下保存12- 26年，发现它们在常规组织切片上完全工作。结论诊断抗体可能有超过10年的有效半衰期。并且对性能的强调应该转移到组织中抗原靶的保存上。
AimsThe aim of this study was to investigate whether the shelf-life of diagnostic antibodies is longer than the expiry date on the label.Methods and resultsFour independent laboratories tested a small number of diagnostic antibodies kept at +4 degrees C for 12-26years, and found them to work perfectly on routine histology sections.ConclusionsDiagnostic antibodies may have a workable half-life in excess of 10years, and the emphasis on performance should shift to the preservation of antigenic targets in the tissue.