The temporal dynamics of Plasmodium density through the sporogonic cycle within Anopheles mosquitoes
The temporal dynamics of Plasmodium density through the sporogonic cycle within Anopheles mosquitoes
复制标题
DOI：
10.1016/j.trstmh.2009.03.009
复制
发表时间：
2009-12-01
影响因子：
2.2
通讯作者：
Basanez, Maria-Gloria
中科院分区：
文献类型：
--
作者：
Dawes, Emma J.;Zhuang, Shijie;Basanez, Maria-Gloria
寄生虫密度对疟疾传播的影响尚不清楚。我们调查了孢子生殖的时间动态和寄生虫密度对这些动态的影响。进行了一系列实验，其中用含有一系列动合子密度的血液喂养蚊子笼。在喂食后随时间解剖存活蚊子的样品以计数卵囊和子孢子数量。结果揭示了一个驼峰（凸）模式的卵囊数量和孢子生殖阶段之间的过渡率是密度依赖性的。这对寄生虫-蚊子界面研究的设计和传播阻断策略的制定具有影响。(C)2009年皇家热带医学和卫生学会。由爱思唯尔有限公司出版。保留所有权利。
The impact of parasite density on malaria transmission remains unclear. We investigated sporogony temporal dynamics and the effect of parasite density on these dynamics. A series of experiments was conducted in which cages of mosquitoes were fed on blood containing a range of ookinete densities. Samples of surviving mosquitoes were dissected over time post-feeding to count oocyst and sporozoite numbers. Results reveal a humped (convex) pattern of oocyst numbers and suggest that transition rates between sporogony stages are density dependent. This has implications for the design of parasite-mosquito interface studies and the development of transmission-blocking strategies. (C) 2009 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.