Handedness is related to formal thought disorder and language dysfunction in schizophrenia.
Handedness is related to formal thought disorder and language dysfunction in schizophrenia.
复制标题
惯用手与精神分裂症的形式思维障碍和语言功能障碍有关。
DOI：
10.1080/01688639408402613
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发表时间：
1994
影响因子：
2.2
通讯作者：
Manoach,DS
中科院分区：
文献类型：
--
作者：
Manoach,DS
研究了29名精神分裂症患者、42名躁狂抑郁症患者和25名正常对照者的利手与正式思维障碍和语言功能障碍的关系。受试者表现出手的偏好（偏好指数），并进行了四项任务的手动熟练度。在四个熟练度任务中的每一个上，计算横向熟练度分数以量化手动优势的方向和程度，其平均值构成横向熟练度指数。还计算了由其标准差组成的变异性指数。在男性精神分裂症患者中，通过偏好指数测量的左偏性与形式思维障碍的严重程度有关。变异指数与精神分裂症组整体的形式思维障碍和语言功能障碍的严重程度显著相关。这些关系在对照组中未得到证实。这些发现支持了这样的假设，即在精神分裂症中，非典型利手是左半球功能障碍的标志，也会破坏语言过程，包括那些与形式思维障碍的表现有关的过程。
The handedness of 29 schizophrenics, 42 manic-depressives, and 25 normal controls was examined in relation to formal thought disorder and language dysfunction. Subjects demonstrated hand preference (Preference Index) and also performed four tasks of manual proficiency. On each of the four proficiency tasks a lateral proficiency score was computed to quantify direction and degree of manual superiority and their mean constituted the Lateral Proficiency Index. A Variability Index, consisting of their standard deviation, was also computed. Sinistrality, as measured by the Preference Index, was related to severity of formal thought disorder in male schizophrenics. The Variability Index was significantly related to severity of formal thought disorderandto language dysfunction in the schizophrenic group as a whole. These relations were not demonstrated in the control groups. These findings support the hypothesis that, in schizophrenia, atypical handedness is a marker of left-hemisphere dysfunction that also disrupts language processes, including those implicated in the manifestation of formal thought disorder.