Intravascular photoacoustic imaging using an IVUS imaging catheter
Intravascular photoacoustic imaging using an IVUS imaging catheter
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DOI：
10.1109/tuffc.2007.343
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发表时间：
2007-05-01
影响因子：
3.6
通讯作者：
Emelianov, Stanislav Y.
中科院分区：
文献类型：
--
作者：
Sethuraman, Shriram;Aglyamov, Salavat R.;Emelianov, Stanislav Y.
高分辨率的动脉粥样硬化导管成像，尽管是侵入性的，对于筛选和表征易损斑块是极其重要的。目前，需要一种能够提供斑块全面形态和功能信息的成像技术。在本文中，我们提出了一种血管内光声成像技术，通过使用正常组织和动脉粥样硬化病变之间的光学吸收对比来表征易损斑块。具体来说，我们研究的可行性，获得血管内光声（IVPA）图像使用高频血管内超声（IVUS）成像导管。实际上，IVPA成像与临床可用的IVUS成像的组合可以提供斑块的期望的功能和形态评估。用仿组织动脉血管模型和离体兔动脉标本进行了成像研究。我们的研究结果表明，基于导管的血管内光声成像是可能的，IVPA与IVUS的组合有可能根据斑块的结构和成分检测和区分动脉粥样硬化。
Catheter-based imaging of atherosclerosis with high resolution, albeit invasive, is extremely important for screening and characterization of vulnerable plaques. Currently, there is a need for an imaging technique capable of providing comprehensive morphological and functional information of plaques. In this paper, we present an intravascular photoacoustic imaging technique to characterize vulnerable plaques by using optical absorption contrast between normal tissue and atherosclerotic lesions. Specifically, we investigate the feasibility of obtaining intravascular photoacoustic (IVPA) images using a high-frequency intravascular ultrasound (IVUS) imaging catheter. Indeed, the combination of IVPA imaging with clinically available IVUS imaging; may provide desired functional and morphological assessment of the plaque. The imaging studies were performed with tissue-mimicking arterial vessel phantoms and excised samples of rabbit artery. The results of our study suggest that catheter-based intravascular photoacoustic imaging is possible, and the combination of IVPA with IVUS has the potential to detect and differentiate atherosclerosis based on both the structure and composition of the plaque.