Association between the NBS1 E185Q polymorphism and cancer risk: a meta-analysis.
Association between the NBS1 E185Q polymorphism and cancer risk: a meta-analysis.
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NBS1 E185Q 多态性与癌症风险之间的关联：荟萃分析
DOI：
10.1186/1471-2407-9-124
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发表时间：
2009-04-24
期刊：
影响因子：
3.8
通讯作者：
Shi L
中科院分区：
文献类型：
--
作者：
Lu M;Lu J;Yang X;Yang M;Tan H;Yun B;Shi L
BackgroundNBS1 is a key DNA repair protein in the homologous recombination repair pathway and a signal modifier in the intra-S phase checkpoint that plays important roles in maintaining genomic stability. The NBS1 8360G>C (Glu185Gln) is one of the most commonly studied polymorphisms of the gene for their association with risk of cancers, but the results are conflicting.MethodsWe performed a meta-analysis using 16 eligible case-control studies (including 17 data sets) with a total of 9,734 patients and 10,325 controls to summarize the data on the association between the NBS1 8360G>C (E185Q) polymorphism and cancer risk.ResultsCompared with the common 8360GG genotype, the carriers of variant genotypes (i.e., 8360 GC/CC) had a 1.06-fold elevated risk of cancer (95% CI = 1.00–1.12, P = 0.05) in a dominant genetic model as estimated in a fixed effect model. However, the association was not found in an additive genetic model (CC vs GG) (odds ratio, OR = 0.98, 95% CI = 0.85–1.13, P = 0.78) nor in a recessive genetic model (CC vs GC +GG) (OR = 0.94, 95% CI = 0.82–1.07, P = 0.36). The effect of the 8360G>C (E185Q) polymorphism was further evaluated in stratification analysis. It was demonstrated that the increased risk of cancer associated with 8360G>C variant genotypes was more pronounced in the Caucasians (OR = 1.07, 95% CI = 1.01–1.14, P = 0.03).ConclusionOur meta-analysis suggests that the NBS1 E185Q variant genotypes (8360 GC/CC) might be associated with an increased risk of cancer, especially in Caucasians.
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影响因子：
2.2
作者：
Debniak, T;Górski, B;Lubinski, J
通讯作者：
Lubinski, J
影响因子：
2
作者：
Kobayashi, J
通讯作者：
Kobayashi, J
影响因子：
4
作者：
Forget, AL;Bennett, BT;Knight, KL
通讯作者：
Knight, KL
影响因子：
4.7
作者：
Figueroa, Jonine D.;Malats, Nuria;Garcia-Closas, Montserrat
通讯作者：
Garcia-Closas, Montserrat
影响因子：
3.7
作者：
Cerosaletti, KM;Morrison, VA;Concannon, P
通讯作者：
Concannon, P